Oral Relumina better that leuprolide ... - Advanced Prostate...

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Oral Relumina better that leuprolide in HERO trial

George71 profile image
11 Replies

"The data demonstrated that the risk for a major cardiovascular event was reduced by 54% in patients who received Relumina compared to leuprolide."

curetoday.com/view/relumina...

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George71
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11 Replies
SPEEDYX profile image
SPEEDYX

Looks good...Hopefully available by end of year big question how much and will insurance cover

noahware profile image
noahware

Any comments on this following aspect of the trial?

Relugolix 120 mg orally once daily...

... vs...

leuprolide acetate depot suspension, 22.5 mg -- OR -- 11.25 mg in Japan and Taiwan, based on local labels.

Why the inclusion of men (one third of the total) receiving what amounts to half a dose? Why not compare to a group 100% of whom are receiving standard dose of 22.5 mg?

George71 profile image
George71 in reply to noahware

maybe one is a 3 month dose and the other is a 6 months dose ?? just guessing -- don't know anything about ADT.

in reply to George71

It looks like the subcutaneous dose is 22.5 mg and the IM dose is 11.25 mg.

pdr.net/drug-summary/Lupron...

George71 profile image
George71 in reply to

thanks - apparently it takes less to do the same thing depending on whether it is subcut. vs IM ? if I understand you

in reply to George71

Looks that way from the prescribing info. I wasn't aware of that until I looked at.

Apparently acts quicker and effects leave the system faster than Lupron. Possible future if BAT is ever needed.

healio.com/news/hematology-...

George71 profile image
George71 in reply to

that too.... i would think a real benefit would be the statement they made ..

"The data demonstrated that the risk for a major cardiovascular event was reduced by 54% in patients who received Relumina compared to leuprolide."

Schwah profile image
Schwah

Did it reduce T as well as lupron ?

SPEEDYX profile image
SPEEDYX in reply to Schwah

I believe it is more rapid and sustains the castration levels....and when it is stopped T comes back quicker!!!

wilcoxsaw profile image
wilcoxsaw

Not even approved yet, gonna be a while

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