Oral Relumina better that leuprolide in HERO trial

[George71]

"The data demonstrated that the risk for a major cardiovascular event was reduced by 54% in patients who received Relumina compared to leuprolide."

curetoday.com/view/relumina...

[SPEEDYX]

Looks good...Hopefully available by end of year big question how much and will insurance cover

[noahware]

Any comments on this following aspect of the trial?

Relugolix 120 mg orally once daily...

... vs...

leuprolide acetate depot suspension, 22.5 mg -- OR -- 11.25 mg in Japan and Taiwan, based on local labels.

Why the inclusion of men (one third of the total) receiving what amounts to half a dose? Why not compare to a group 100% of whom are receiving standard dose of 22.5 mg?

[George71 in reply to noahware]

maybe one is a 3 month dose and the other is a 6 months dose ?? just guessing -- don't know anything about ADT.

[Hidden in reply to George71]

It looks like the subcutaneous dose is 22.5 mg and the IM dose is 11.25 mg.

pdr.net/drug-summary/Lupron...

[George71 in reply to Hidden]

thanks - apparently it takes less to do the same thing depending on whether it is subcut. vs IM ? if I understand you

[Hidden in reply to George71]

Looks that way from the prescribing info. I wasn't aware of that until I looked at.

[Hidden]

Apparently acts quicker and effects leave the system faster than Lupron. Possible future if BAT is ever needed.

healio.com/news/hematology-...

[George71 in reply to Hidden]

that too.... i would think a real benefit would be the statement they made ..

"The data demonstrated that the risk for a major cardiovascular event was reduced by 54% in patients who received Relumina compared to leuprolide."

[Schwah]

Did it reduce T as well as lupron ?

[SPEEDYX in reply to Schwah]

I believe it is more rapid and sustains the castration levels....and when it is stopped T comes back quicker!!!

[wilcoxsaw]

Not even approved yet, gonna be a while