Fact? Lab diff? Or No problem,yet?

[depotdoug]

PSA & T-Levels in. 01/22/2020 results POST 37days Abiraterone/250mg are:::

__ __ __ __ __ __ __ __ __ __ __ __ __ __

1. PSA = 1.50 ng/mL. 01/22/2020

2. T-level. < 3.0ng/dL

__ __ __ __ __ __ __ __ __ __ __ __ __

Compared to Dec10th

1. PSA = 1.10ng/mL

2. T-level < 10ng/dL

Question: why 0.40 ng/mL 🔺rise or difference?

I’ve been on 250mg Abiraterone daily 37 days.

Yes, it’s two different labs.

Maybe it’s “only 37 days on Abiraterone?

Does it take longer than 37 days to knock down PSA levels from 1.10??

Am I too too wishful? Asking for fast “knockdown” kick in the butt Zytiga results?

Doug

[Dachshundlove]

Hi Doug

First of all, lab differential is real, so consider that scenario a likely possibility.

Are you on the 250mg with food to increase absorption?

Have you had any genetic testing? Do you know if you have TP53 or Pten mutations? Certain mutations are associated with muted response to abiraterone.

I think abiraterone should take psa down quickly. I believe it ideally would come down by 1/2 in the first 15 days.

I think it’s too early and not enough information to judge effectiveness of current treatment.

[depotdoug in reply to Dachshundlove]

Yes. I swallow my 250mg Abiraterone tab with breakfast. Low fat. Apple & healthy cereal w/skim milk. Sometimes poached egg/. 1/2 low cal

Muffin.

2. Yes I had genetic testing done 09/10/2019. Guardant360 liquid biopsy lab test. That test found no genetic DNA 🧬 mutations tags that could ID any cancer traits in me. Ok that’s ok. No known or ID’d mutations.

3. I’ll be doing repeat PSA/T-levels labs plus all the massive CBC and lymphocytes etc, March 10th. At my IU Health Oncology Doctor visit..

That’s just 6 weeks out. And therefore I’ll be on ~~ 3 months of Abiraterone 250mg... sounds good for now..

Thxs Doug

[LearnAll in reply to depotdoug]

Doug,

You need to increase some fat in your breakfast to improve absorption of Abiraterone. Small amount of fat does not cause much harm if you are fully physically active.

[depotdoug in reply to LearnAll]

Will do that exactly starting with tomorrow mornings' breakfast.

I'll add a Chobani yogurt. Then some select hunk of ham. How about some peanut butter on toast? Sounds good Thanks LearnAll.

[Currumpaw in reply to depotdoug]

Hey depotdoug!

How about avocado toast with some freshly ground pepper and Mrs. Bragg's Nutritional Yeast Seasoning?

Many of us try to avoid dairy, peanuts and 'processed meats'!

A few entries on your search bar may convince you, if not fine.

Currumpaw

[depotdoug in reply to Currumpaw]

Avocado toast it is. Avocados have healthy FATS I think. But never heard of Avocado toast? I’ll. Look today.

[Currumpaw in reply to depotdoug]

Hey depotdoug!

I'll make it easy for you. Note the benefit to the immune system but especially which cancers avocados are supposed to help prevent.

livescience.com/45209-avoca...

Currumpaw

[depotdoug in reply to Currumpaw]

Just reviewed avocado 101 news from the livescience.com/45209-avocado link you sent.

? Why do not Med ONC and Urologist promote Avocado 🥑’s as a CANCER Killer / or Containing food?

[Currumpaw in reply to depotdoug]

Hey depotdoug!

Those folks don't study nutrition. Also--avocado is a "helpful" food to eat. If avocados were a certain cure for a rabid Gleason grade 10 do you think people would be literally poisoned with chemo and radiation hoping those treatments would kill their cancer but leave them alive?

If ayurvedic was a cure same thing? Some of these foods and supps can be helpful stabilizing and delaying progression but as of yet the most surprising patient to me--not prostate cancer--former President Jimmy Carter. An elderly man whose cancer had him within weeks of passing and now his biggest concern is staying upright! I wish him some more time on this earth--keep him away from Habitat for Humanity or at least off the ladders!

Currumpaw

[depotdoug in reply to Currumpaw]

Look at the difference between cost of an Avocado and Chemo and Radiation zaps.

Plus I’m not gonna stay off the top of my ladder. But I’m a few years away from J. C. aka Jimmy Carter...

[Currumpaw in reply to depotdoug]

Hey depotdoug!

An avocado won't replace what chemo or radiation can do if they are necessary. If the heavy duty stuff has to be done and nothing else will work ---????

Currumpaw

[depotdoug in reply to Currumpaw]

Yep, just like if my heart(cardiac) wise doesn’t work or goes crazy all else is in vain. It’s obvious to me probably all of us Advanced PCa guys if a major organ goes down we aren’t gonna care about what the Avocado or Abiraterone or Chemo or Radiation does.

All things work together for our bodies, minds and souls. I’m struggling with where I’m at right now.

You can probably see that.

Appreciate letting me speak ask for support. We all need it boy do we all!

Thanks Depotdoug.

[Currumpaw in reply to depotdoug]

Hey depotdoug!

You are most welcome. Any thing I can send your way just ask. Remember that some things interact badly --not often-- but a good doctor who understand nutrition is important. A naturopath can be helpful but will the naturopath understand medications?

One has to be careful. This is a good site as many of the men have much info and have had doctors such as Dr. Charles "Snuffy" Meyers.

Currumpaw

[depotdoug in reply to Currumpaw]

I’ve heard and read some of Dr Meyers knowledge.

[tango65]

The clinical trials showings an advantage over ADT alone were done with 1000 mg a day. May be I am wrong but I believe there are not data showing that OS is the same if taking 250 mg a day with a fatty breakfast.

[depotdoug in reply to tango65]

I can could maybe be grasping for minute(small) details. No I’m trying to over evaluate my situation. With 250mg Abiraterone in AM I thought it would kick drop my PSA radically down from 1.10ng/mL 12/10. It did not yet!

Understandingly does. I can always go up up on Abiraterone to whatever my MO wants. 500mg or 1000mg / day.

Next OV is March 10. Lab tests them will be persuasive or decisive.

I waited on a call yesterday from my MO RN, she didn’t respond, yet. I think they have more pressing cancer patients to help than me.

I could do a “Request a Test” personal(my cost$) PSA Lab repeat in 2 weeks, just a sanity ck.

What do you think Tango65?

[tango65 in reply to depotdoug]

If you can afford the cost of 1000 mg I will go with the dose of the clinical trials showing an advantage in survival. One has only one shot with these therapies. Talk with you MO and follow his/her advice.

[depotdoug in reply to tango65]

My MO originally prescribed me 1,000 my Abiraterone. But after future review, considering my major Cardiac conditions , 1. On my 2nd ICD/pacemaker 2. NSVTachycardia 8.5 years ago, 3. AFIB 2013-2016. 3 Cardioversions 1 Cryoablation .

He, my MO said it was OK to start on 250mg. Throw in my Neurogenic bladder, Super poly neuropathy feet and legs. Plus Anxiety meds.

You see my point tango65.

I have no qualms absolute no reservations about going up up in Abiraterone! Next visit with MO is March 10 my B-day..

Yeh I’ve got a medical Abiraterone

Grant through 01/30/2021. The cost

Is not a problem.

I’ve got a call in yesterday to

My MO’s RN for answer to my PSA difference. 12/10. 1.10ng/mL. Vs

01/22/2020 1.500ng/mL.

Is there anything wrong with increasing my Abiraterone up up

March 10th?

Thanks for responding...

Will update soon. On the treadmill at my LIVESTRONG YMCA @ the moment better stop

typing....

[tango65 in reply to depotdoug]

The cardiovascular complications caused by abiraterone treatment can be controlled by an adequate dose of prednisone. If in your case using prednisone is a problem to control the increase in aldosterone caused by abiraterone, they could use eplerenone (Inspra). Talk with your internal medicine doctors and your MO . How much prednisone are you taking right now? I never took a abiraterone, but if I will have to take it I will take the 1000 mg, which is the dose shown to help to prolong life. I understand people who can not afford 1000 mg dose trying to go by using 250 mg and a fatty breakfast, but if you can afford 1000 mg I believe you should follow the protocol showing an advantage in overall survival.