Prednisone induced facial swelling

[Vsahay]

Anyone on prednisone and abiraterone suffering from face swelling?

How to reduce prednisone induced swollen cheeks?

[6357axbz]

Type “moonface” in the search bar for more info.

[Tall_Allen]

How much prednisone are you taking?

[Vsahay in reply to Tall_Allen]

5 mg twice a day

[Tall_Allen in reply to Vsahay]

Maybe discuss reducing that to 5 mg once a day

[Vsahay in reply to Tall_Allen]

Had tried this earlier but began to feel very dizzy so had to go back to 10 mg

[tango65]

You could discuss with your MO to reduce the dose to 5 mg of prednisone. One of the RCT of abiraterone (Zytiga) was done with this dose of 5 mg.

nejm.org/doi/full/10.1056/N...

Your doctors have to check for hypertension, edema and hypokalemia. If one of this complications appears when taking 5 mg of prednisone you could discuss adding Inspra (eplerenone). Inspra is an aldosterone receptor blocker. Patients treated with abiraterone (Zytiga) receive prednisone to control the increase in ACTH caused by low or absence of cortisol production by the adrenal glands. If ACTH is elevated it will cause an increase in aldosterone which could lead to sodium retention, edema, hypertension and hypokalemia. Blocking aldosterone receptors could help to control these potential complications.

[Vsahay in reply to tango65]

Having slight swelling near ankles and high blood pressure 172/86.What tests should be done?

[dentaltwin in reply to Vsahay]

Of course glucocorticoids can cause edema, but so-called "pitting edema" in the ankles can be a sign of heart failure. Your blood pressure isn't well-controlled. Do you have a cardiologist?

[Vsahay in reply to dentaltwin]

Visited a cardiologist 2 days ago.Based on ecg reports,his heart is fine.

[dentaltwin in reply to Vsahay]

Was he/she asked about the ankle swelling? Any changes in the BP meds?

[PhilipSZacarias in reply to tango65]

Excellent reply. What about switching to dexamethasone?

[larry_dammit]

Both my dad and I had the swollen ( jolly ) look while on prednisone, once we quit it went away

[Vsahay in reply to larry_dammit]

Any way to control moonface?

[Hotrod65]

5 mg daily...don't have swelling, but always hungry..so have to watch that or I will have weight issues.

[Hidden]

Don’t reduce yourself, you have to step down. MO can help with schedule. Puffiness is a side effect..... I took 30 mg of Prednisone for six months during a clinical trial....... probably the biggest contributor to difficulties are any co-morbidity present. 5/10 mg daily is considered SOC as it is known to be within safe limits of the body and its reaction.

Similar to a “Z Pack” with its decreasing daily doses over ten days. Starting and stopping Prednisone should be under a Physician’s care.

Good luck.

GD

[captain2020 in reply to Hidden]

I am on zytiga one 250mg tab per day. I was ordered prednisone 5mg but have not taken it because I have read that it may cause prostate cell mutations.

[Hidden in reply to captain2020]

Please check and double check your source. Unless research has changed in the last 15 years, Prednisone, according to one of the eirld’s Leading researchers at the time, told me that Prednisone has cancer cell killing properties. I would think that the opposite would have had an adverse effect on me.

Good luck.

GD