Olaparib Question

[Goldberg]

Good morning fellow fighters I have a question concerning Olaparib. I have Mets To the bone and lymph Glands.I am BRCA 2. My PSA Is rising over the last three months from now 25 to 55. I was on Xtandi My i oncologist here aAdvised me to get Radium 225For the bone cancer. I sought a second opinion from UCSF And the oncologist there put me on Olaparib And advised me not to take the Radium treatment. I Took his advice and I have now been on Olaparib the last month. My PSA has gone up another 10 points. I meet with my local oncologist once a month for shots. He Is still encouraging me to take Radium. His Reasoning is that I should do the Radium along with Olaparib. He seems to be of the opinion that the oncologist at UCSF just wants to track the effectiveness of Olaparib but I should be using every thing in the arsenal and if it works who cares which one is helping as long as the results are lowering the PSA. I Would appreciate any opinions That anyone has as I am on a fence as what to do.

[tango65]

Olaparib seems to work in about 78% of prostate cancers with BRCA mutations:

urotoday.com/conference-hig...

Are you in a clinical trial for Olaparib at UCSF? If you are, it is possible that the trial does not allow treatment with Ra 223.

There is a trial at UCSD (San Diego) using Olaparib and Ra 223

clinicaltrials.gov/ct2/show...

[Goldberg in reply to tango65]

Thanks for the reply II am aware of the trial Iam not eligible because I’m already on Olaparib.

[tango65 in reply to Goldberg]

Best of luck!!

[Tall_Allen]

I think the data on Xofigo look great, and it seems that earlier use has better outcomes. I think it pairs well with immunotherapy - like Provenge.

[p3d1]

Hi Goldberg, I am also BRCA2 and on the Rubraca TRITON 3 trial. My Doc advised me that they are using CT and Bone scans to track any progression. PSA can be released when PCA cells die, similar to when you are on Chemo so it is not a reliable tracker for a treatment that intend to kill a lot of cells. Are they intending to use scans where you are being treated?

[Goldberg]

Yes this is my first month.

[Drcrunch]

Have been on lynparza for six months. Psa went from 365 to over 2000. May be over 2000 since they do not check it over that amount. But I am staying with treatment because scan shows large tumors have shrunk. I have no pain. Side effects are rough, mainly grade 3 fatigue that happened about 3 weeks ago. I decided to try increase my iron and folic acid supplements and this week, the fatigue has let up about 70%. Blood panel today shows that alkaline phoshatase has dropped 20 points. It had gone up every month. It is worth staying with a PARP inhibitor.It is a game changer for Brca mutation people. Read about a man who has been on it for ten years (maintenance).

[j-o-h-n]

On whatever you choose -

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 07/19/2019 1:45 PM DST