Talapro 2 one week in

[Maleko808]

One week ago Sept 23 I started the Talapro 2 clinical trial (talazoprib/placebo with enzalutamide) and immediately jetted of to Hawaii. Notice a bit more fatigue than just the lupron. And maybe a bit looser bowl. But so far all side effects are very manageable. PSA was at 14, mets to pelvic bone, L4, ribs, femur and skull. Next blood test on Oct 8. I'll keep you posted on how things are going.

[Maleko808]

Many types. Off to Hawaii instead of, bowl instead of bowl. I'm blaming it that I'm on aloha time right now 😀

[tango65]

Does your cancer has BRCA or ATM mutations? Talazoparib is a PARP inhibitor. Olaparib another PARP inhibitor has shown efficacy in cancers with BRCA , ATM and other DNA repair mutations.

urotoday.com/conference-hig...

en.wikipedia.org/wiki/Talaz...

talzenna.com/?source=google...

Keep us posted .

Best of luck.

[Maleko808 in reply to tango65]

Freedom one said it was inconclusive but all indicators is BRCA mutation likely.

[tango65 in reply to Maleko808]

Best of luck, my friend.

[kidclutch in reply to tango65]

my dad carries the ATM defect and tried a talazoparib + avelumab trial early this year. it was a failure for all ATM patients, they were kicked off. BRCA patients were responding though, so best of luck!

[tango65 in reply to kidclutch]

Most cancers with BRCA respond to olaparib (77% had a decrease in PSA) and most cancers with ATM do not respond (only 5.3% had a PSA decrease).

urotoday.com/conference-hig...

[Cgjunior in reply to tango65]

I’m on the talazoparib+Avelumab trial since Late April. BRCA2.

So far scans show the disease progression to the bones has been halted. ALP down to 90 but PSA holding around17-20. (?)

Worst side was anemia

[kidclutch in reply to Cgjunior]

i’m so glad it worked for part of the trial participants!! late april is when my dad got booted from the same trial. onco said the BRCA patients were doing much better than ATM. dad felt almost immediately better after ditching the talazoparib. had a pretty rough infusion reaction the first time, too. fine the second. there was no third.

[Seebs9]

Must have a rich girlfriend... lucky guy. Have a great time.

[monte1111]

Wow. Enjoy Hawaii. Be careful of volcanoes. The Luau Pig beckons. No diets in Hawaii. Enjoy.

[j-o-h-n]

How va yee?

Good Luck, Good Health and Good Humor.

j-o-h-n Sunday 10/06/2019 10:20 PM DST