NOTCH pathway inhibition as therapeutic alternative that antagonizes the metastatic potential of T2E PCA.

50% of PCA has T2E fusion (TMPRSS2–ERG) which activates NOTCH pathway.

Notch pathway inhibition could antagonize the metastatic potential of these tumors.

sci-hub.se/10.1038/ng.3930

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Natural inhibitors: sulforaphane, quercetin, curcumin, resveratol, genistein.

ar.iiarjournals.org/content...

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As dewormer: NICLOSAMIDE

ncbi.nlm.nih.gov/pmc/articl...

ncbi.nlm.nih.gov/pmc/articl...

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Also interesting: aspirin:

ncbi.nlm.nih.gov/pmc/articl...

See Myers: askdrmyers.wordpress.com/20...

[LearnAll]

Very useful information, Myrammole...Thank you for sharing.

Is it possible to identify T2E pCA from Non-T2E pCA by looking at clinical characteristics or any other way ? Is there a test ?

[Hidden in reply to LearnAll]

I think, besides DNA test you can do an urine test.

ncbi.nlm.nih.gov/pmc/articl...