PSA fluctuations

[Mark50]

Although my PSA levels have gone to 0.03 from 0.01 over 2 years, why do they fluctuate?

[LearnAll]

Its nature of PSA to fluctuate as cells are constantly releasing PSA and at the same time PSA is getting broken down and excreted. Fluctuation within a narrow range should not be cause of concern..it happens in everyone. Also,consider lab's margin of error.

[Mark50 in reply to LearnAll]

Thank you

[Mark50 in reply to LearnAll]

I had a prostatectomy in 2017 and my PSA has gone.from 0.01 to 0.03. Should I be concerned?

[LearnAll in reply to Mark50]

Mark...I will repeat PSA every 14 days for two times...If it seems a upward trend..it should be some concern Just one reading does not make a trend...and its trend which matters in this disease.

[Mark50 in reply to LearnAll]

Thank you for your advice. I'll have my bloods checked out.

[Magnus1964]

This is a small fluctuation, I would not be concerned about it. What you need to watch is any steady progression over 5 or more tests.

[Mark50 in reply to Magnus1964]

Thank you. You've put my mind at ease.

[Tall_Allen]

If your pathology was good, only a distinct trend is important - at least 2 consecutive increases over 0.03 or an increase of over 0.05 in a year.

[Mark50]

My gleason score was 7 (3+4) and no positive margins post prostatectomy. Also no nodal involvement.