Apalutamide plus ADT- Effective but less toxic than chemo or zytiga + prednizone?

[efsculpt]

An interview I read grabbed my attention. The two Docs were reviewing recent trial findings on Apalutamide plus ADT. It appears effective for castrate sensitive patients. They went further by comparing the negatives of Chemo plus ADT, and Zytiga/prednizone plus ADT. I can attest to the negatives of chem and prednizone.

I am going "OFF" ADT plus Zytiga/Prednizone mid July. If/when I need to go back "ON" it would be nice if I didn't have to do chemo (generally hell) or go back on prednizone (skin thinner) and still have the treatment as effective.

practiceupdate.com/C/84441/...

Regards to all,

Craig

[tango65]

They have different side effects. A couple of MOs I consulted, told me abiraterone plus prednisone is in general better tolerated than enzalutamide or apalutamide. Some of the negative effects of abiraterone could be controlled by adjusting the dose of prednisone.

rxlist.com/erleada-drug.htm

rxlist.com/zytiga-drug/pati...

[Jbooml]

with all the recent note of prolactin's cancer promotion maybe they can rollup a combination pill to include PRL blocking effects.

[Jbooml]

Don't think prolactin in any amount should be considered safe with PC hunting alternative regenerative sources.....something is contributing to T desensitization and the horrors of castrate resistance....its not a matter of degree rather one of existential participation...... in my opinion.

[Jbooml]

I think we can both agree this theory should be considered for immediate trials. the PRLs blockers are widely available where fashioning a compassionately calculated study could rapidly see results.