First, the researchers inhibited the tumour cell mitochondria, by restricting the cancer cells only to glucose as a fuel source; then, they took away their glucose, effectively starving the cancer cells to death.
"In this scenario, Vitamin C behaves as an inhibitor of glycolysis, which fuels energy production in mitochondria, the "powerhouse" of the cell, explained co-author Dr Federica Sotgia.
The Salford team recently showed Vitamin C to be up to ten times more effective at stopping cancer cell growth than pharmaceuticals such as 2-DG, but they say that when Vitamin C is combined with an antibiotic, it is up to ten times more effective, making it nearly 100 times more effective than 2-DG.
As Doxycycline and Vitamin C are both relatively non-toxic, this could dramatically reduce the possible side-effects of anti-cancer therapy.
Sounds interesting, but would be more interesting if not every article related to doxycycline inducing "metabolic inflexibility" lists Ernestina Marianna de Francesco as an author.
sci-hub.tw/10.0000/ncbi.nlm.nih.gov/PMC6520007 this one has not Ernestina but the chief is named always last so it is Dr Lisanti behind these researches.
thanks for the update -- it combines low dose Azithromycin with Doxycycline and vitamin C to kill 90% CSC -- would anyone know what dose of Doxy it takes to get 1 part per mil.
Doxycycline is usually given as 100 mg po BID for a period of time...looking at the article....the question for me was what dose of Doxy and Vitamin C daily and for how long ??? Also, whether Liposomal C might be the better choice to take. Thanks for posting, George71...
"The antibiotic, Doxycycline, followed by doses of ascorbic acid (Vitamin C), were surprisingly effective in killing the cancer stem cells under laboratory conditions, according to the research published in the journal Oncotarget."
This shows promise. But it's real early petri dish results. Not even with mice.
It's my understanding that IF YOU DON'T HAVE PCa Vitamin C oral is good BUT if you have advanced cancer the relatively low dose works just the opposite. High dose IV only works IF YOU HAVE advanced cancer.
Course I'm not a doc and just repeat my experiences or what I've read from what seems creditable.
I've done many high-dose Vitamin C infusions. I started combining it with doxycycline about 2 years ago.
It doesn't cure my cancer. It might slow progression. No way to be sure, the N=1 problem.
It certainly does not hurt anything except your time and wallet. An infusion takes several hours and the costs are rarely covered by insurance.
I know from my own measurements that it is possible to raise serum ascorbate levels to those shown to be highly toxic to cancer cells in vitro. I don't know much about serum levels of doxycycline or how it does or does not enter tumors, but it is safe and inexpensive. The theory is sound, the practice is safe and reasonable, and the confirmation by clinical trial is years or decades away, if it ever comes at all. I don't have that much time.
So I will continue to use it, and other treatments with low risk of negative outcomes and reasonable expectation of positive outcomes.
I remember reading this last year and thought it would take hold but it seemed to disappear. I asked a number of times what was happening with it -nothing.
This talks about cancer and sugar. Dr Myers said for Pca cholesterol was the prime fuel until late stages.
I've taken Doxy with vitamin C for 8 day cycles -- 100 mg daily Doxy and 1 gram vitamin C every 2 or 3 hours throughout the day. I have also done IV C in the past but I read where the body can only use maybe 500 mg at a time and loses the rest within 2 or 3 hours... so a continuous ingesting of1 gram oral dose 10 or 12 times per day is thought to be better. I bruise easy when doing continuous high dose C but other than that the PSA doubling time has slowed considerably since Doxy / Vitamin C -- Dukoral -- Boron being added to other supplements curcumin, resv., 10,000 D3 and k2, DIM and Avadart.
Has anyone else tried Doxy and vitamin C -- in what amounts?
I've done two 8 day cycles -- in last 6 months -I waited 3 months between doing it - my dermatologist said many patients take doxy continuously daily for years for acme and roesha. My son took it for nearly a year in high school to clear complexion.
and how much did the PSA doubling time slow down, to understand better, what is your Gleason score, did you have radiation or RT and are you on ADT or other standard drugs?
Hi George. I am gearing up to do the 'Lisanti' DAV protocol. The antibiotics are easy - 250mg of Azithromycine (take at least 2 hours in advance) and 100mg of doxycycline will put you in the ballpark. The Vit C has been worrying me until I saw this video (below link). My plan is to take 1 g per hour of ascorbic acid to establish a baseline, and take 1g per hour as Dehydroacetic acid (see video). That should give me in excess of the 250umol required. AA and DHAA absorb via different pathways, so the amounts should be additive. The only reason to combine the two types is that DHAA is a ball-ache to make and I will have less of it to play with, and 1g per hour of each should be tolerable. And I think the DHAA declines faster than the AA. I will keep it going through the day for as long as I can. I had HIFU for localised (I hope) G3+4 last November (2 lesions one 1cm), PSA dropped from max 8.1 (4.4 pre-op due to(?) LDN + Hymecromone) to post HIFU 1.4, 1.2, 1.0. I currently take loads of stuff - no complacency here - and as ever - leave no turd unstoned.... Good Luck.... And if anyone has a recipe for naked zucchinis - please pass it on.
Oops - sorry about the typo or spell corrector.... should read DEHYDROASCORBIC acid not dehydroacetic acid..... Waiting for the iodine solution to arrive to test the reaction....
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but the chief is named always last so it is Dr Lisanti behind these researches.
Invitro study. "Carob bean extract suppressed the proliferation of prostate cancer cells in a time and dose-dependent manner".
