lupron or casodex

[pwallace]

my husband was given the choice of 6 months of lupron, or 2 years of casodex. along with radiation to prostate bed + nodes. (cleveland clinic)

if you were offered this choice, which one did you choose & why? any regrets?

[Tall_Allen]

On the one hand, he had adverse pathology. On the other, his PSA is still low and there were no obvious cancerous lymph nodes. So 6 months of lupron may be enough, as long as the SRT dose is sufficiently high (70-72 Gy) and the pelvic LNs are treated as well.

[pwallace in reply to Tall_Allen]

yes the dose would be 70 GY in 35 fractions at 2 Gy per day & nodes would be treated as well even though his case is of unknown/probably limited benefit according to the RTOG 0534 trial (PSAs lower than .01). still we want to be aggressive bc his dad died v young of this hideous disease & we're afraid of following in his footsteps.

[pwallace]

hi there, can you click on my profile to see my husband's story? i'm not sure if i put the bio in the right place or not. new to this site. yes he's already done surgery & he had 17 months of freedom b4 psa starting to rise again. adverse pathology: EPE in 2 places, tertiary 5, intraductal carcinoma & high risk (decipher score). so in this case, would lupron be the more aggressive treatment even though it's only 6 months? all over these forums i see people combining these 2 & even adding others. i wonder why the cleveland clinic advises against that...

[j-o-h-n]

First of all....Did you sell those cute kids already? Next: I've had 39 sessions of frying my bed. For me it was as if I got an x-ray from my dentist. NO problem then, but a couple of years later it appears that my left urinary tract was fried. Had to have stents in and out, out and in for several years (no problem with stents). My left kidney produces 20% of my urine the right kidney the remaining 80%. Just my experience with the microwave oven...LOL

BTW your age? where being treated? Doctor(s) name(s)? Info voluntary.

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 03/08/2019 8:59 PM EST

[pwallace]

what cute kids!? i thought that was your family picture- ha! as for age & stats, i added them to my profile (i think i added it in the right place). glad to hear you didn't have a problem w/the fryer. did you do prostate bed & nodes, or just bed? our heads are spinning w/all the choices we have to make, similar to the first go 'round w/surgery, but for some reason this seems more dire.

[pwallace]

i appreciate your reply. and that's our thinking too. go aggressive, especially considering his pathology (and his father's before him). is the trial for lupron and casodex at the same time, or one right after the other, do you know? my husband fears the side effects of lupron the most, but he also wants the most potent treatment. guess you can't have one without the other? thanks nalakrats

[pwallace]

naturally? your t went up to 700? that is amazing! my husband has low t by nature, it hovers around 100 without supplementation, so i told him hormone therapy might not affect him as badly as he thinks it will! thanks for telling me about the vantas implant, i'd never heard of it before. will look into it.

[Break60]

I did six months of Lupron but did not get IMRT to LNs then because the ten LNs dissected during ORP were benign. Fifteen mos. later I had PCa in two LNs and went on triple blockade for 13 mos. along with IMRT to 75 grays to all pelvic lymph nodes. Also started metformin, cabergoline, calcium, D3.

His pathology, like mine, is poor. So be aggressive. I’m still here nearly six yrs. after dx and feeling fine.

Bob

[pwallace in reply to Break60]

thank you for your input, we are taking this to heart. as much as it sucks to be in this position again, we know he has to hit it hard. and fast. glad to hear you're doing well 6 years out.

[Break60 in reply to pwallace]

Yes it’s sad that you have to deal with this again. This disease is the pits.

God bless.

[pwallace]

we are aware of these theories, and my husband has had to supplement as well. he is such a different person when T is low (naturally) as opposed to when he's supplementing. my hope is that he can one day return to it...