1 month Zytiga update. Goods and bads.

[Edbl]

Ok.

So my dad has been on Zytiga 1 month since a spike in PSA and a bone scan that showed it has moved basically everywhere

1. PSA went from 13 to 2.8

2. Alkaline phosphate readings have gone from 155 to 285 to 455 to 608

3 weight has gone from 224 to 211 ( not sure how to digest this he is eating cleaner so not sure if it’s life style changes with diet or the bone cancer )

Any similar stories or advice

Thank you

[GoBucks]

PSA drop is great but alkaline phosphate climb not great. What other treatments has he had? Lupron I assume. Any chemo?

[Edbl in reply to GoBucks]

Yes. Seeds and Lupron

[Edbl in reply to Edbl]

Cleveland Clinic disregarded the Alkaline readings. Said they were a non issue? Not sure why

[GoBucks in reply to Edbl]

I see NPfisherman response below. I'd listen to your Cleveland Clinic Docs, not me. Hope the PSA keeps going down & the weight loss is good. I lost 14 pounds when I started Lupron(exercise + better eating). A year+ later and the lost pounds are searching & finding their old home.

[NPfisherman]

Edbl,

I have some info here on zytiga and ALP bounce...you may find this informative..

ncbi.nlm.nih.gov/pubmed/269...

Hope this all turns around like the article described...

All the best,

Fish

[Edbl in reply to NPfisherman]

Thank you. Cleveland Clinic saw Alkaline issue as nothing. Not sure why?

[NPfisherman in reply to Edbl]

Wow, I go to Cleveland Clinic also... maybe they have seen the bounce described in the article I posted you...from reading it, it sounds like it is not a bad thing at all...

Prayers for your Dad...good luck

Fish

[Lisa0627 in reply to Edbl]

Hi .. my Dad started Zytiga on Jan.31. His lab results from 2/22 show that his Alkaline Phos tripled since being on Zytiga. I read the article that Fish sent - very interesting. This is so frightening wondering if he is receiving the right treatment. He’s scheduled for more labs on March 8th. Edbl, did your Dad’s go down ?

[Edbl in reply to Lisa0627]

Won’t know till 4/3. I will let you know. Good luck.

[Onwarddd]

I just stopped Zytiga. PSA went from 20 to .2, but ALT was at 2.5 ULN and climbing. Now weaning off progesterone. Oncologists agreed that since I was only 6 weeks into initial treatment, transitioning to docetaxel made sense rather than trying to fight with Zytiga so it's off to Chemo next week! (whoopee... NOT) Funny, but I lost weight on Zytiga as well.

[Edbl]

Thank you. No chemo so far. Question to you is why are they doing something different at a PSA of .2

[Shooter1 in reply to Edbl]

Was getting 25% drop in PSA per treatment. After 4 cycles test show rise before #5. Back to 0.205. Added Xtandi and went back to consistent drops for next 6 months. Including 4 months after end of chemo and just xtandi.. Had to cut Xtandi acct excess toxicity. Settled at 86 mg average daily dose. PSA came back up a little. Settled at 0.120-0.130. Just my reason for change at 0.2 PSA.