An end to castrate/drug resistance??

[Jlcwonderboy]

Interesting discovery at the ICR in the UK - icr.ac.uk/news-archive/prot...

Thoughts?

[tango65]

The AR-V7 has been for some time associated with failure of casodex, enzalutamide and abiraterone to control the cancer. There are liquid biopsy tests to determine if the cancer has this splice of the androgen receptor.

nanthealth.com/liquid-gps/

There is also information that niclosamide can destroy this variant of the androgen receptor ( at least in tissue cultures) and made the cancer to respond to enzalutamide and abiraterone again

There are phase II clinical trials of niclosamide and enzalutamide or abiraterone.

The people doing these trials have published results of the phase I trials.

ascopubs.org/doi/abs/10.120...

health.ucdavis.edu/synthesi...

[George71 in reply to tango65]

That is really encouraging -- I wonder why most men on this site don't get on niclosamide as soon as they begin to become castrate resistant on ADT (Lupron))

[kaptank in reply to George71]

Niclosamide's on-label description is a worming tablet (anti-helminth) for stomach worms. Its problem is bio-availability. It doesn't have any. It passes straight through the stomach, killing the worms as intended. Its very hard to get it into the bloodstream.

[Hidden in reply to kaptank]

Yikes.

[tango65 in reply to kaptank]

It is true that niclosamide is poorly absorbed in the gut. Niclosamide administered in the doses used in the clinical trials achieved a concentration in blood that is adequate to treat cancer according to tissue culture studies.

ascopubs.org/doi/abs/10.120...

[tango65 in reply to George71]

it is not the standard of care and niclosamide is not available in the USA. It could be obtained in Europe but the cost is around $ 7000 a year.

[kaptank in reply to tango65]

I think the trials may be using niclosamide altered to improve bio availability. They mention niclosamide/PDMX1001. I don't know what that is but I do know big pharma was looking for molecular add ons to increase solubility. Ordinary niclosamide is available over the counter for dog worming. I got some from ebay but I concluded no benefit from my experiment with it. The altered niclosamide (/PDMX1001) would be very expensive I would suspect.