New Study.....Double Time To Castrate Resistance

[gusgold]

New Study On Lupron/Zytiga and time to Resistance...basically start Lupron/Zytiga and stay on for 4 months then get off...monitor PSA...when it goes up by 50% get back on and when PSA drops by 50% get off.....this protocol more than doubled time to Castrate Resistance

Gus

[GeorgeGlass]

Gus, doubled the time to castrate resistance compared to what?

So, this protocol means that you do four months, then stop the Lupron, zytiga and prednisone until the PSA rises again. Since my psa drops and rises quickly in both directions then wouldn't it depend on my raw psa #s instead of percentages because my PSA might drop to 1 or 2 within only two months for example. If its a four month Lupron shot then that's in my body for another two months. Are you suggesting just stopping the Zytiga and Prednisone once tha PSA hits a low number or previous nadir?

thanks,

George

[ronton2 in reply to GeorgeGlass]

GusG, Please post a link to this new outcome.

[EricE]

Thanks, Gus. Do you have a link to that study?

[Hidden]

Link to this new study?

[Balsam01]

I'd be interested in seeing a link too!

[Apollo123]

Can you post the link I’m on Zytiga and would like to take the info to my mo. Thanks 👍

[MyDad76]

My father is on Casodex only (quite typical in our part of the world). We were told than when PSA reaches 1, his therapy will be changes (either increase dose or add Lupron). My I ask what was your PSA before staring treatment?

[MyDad76]

Thank you for replying. I wish you a looong drug free vacation!

My father only had PSA of 5.2 before starting on Casodex. But he was stage 2b, Gleason 7 (4+3) so they started immediatelly. 3 months on Casodex 150mg and PSA was down to 0.17. They reduce the dose to 50mg and now after being on reduced dose for a year his PSA is 0.53. His doctor would continue the same theraphy but I will seek a second opinion.

[MyDad76]

Interesting, thank you. What is also interesting in this perspective is, that my father's brother had both thyroid and prostate cancer!

[podsart]

Nalakrats

Excellent point re TSH -- I found a definite relationship between TSH and PSA

[sakod]

Can you please include the article or site where you found this information? My husband was diagnosed in August 2017 with adv Prostate cancer and bone Mets. Started lupron in September and Zytiga with prednisone in Dec. PSA started at 29 and was 1.08 in January.