Allergic to Docetaxel......other trea... - Advanced Prostate...

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Allergic to Docetaxel......other treatment options alongside ADT

Evans71720 profile image
11 Replies

Apparently too allergic to docetaxel to continue with chemo therapy. Read several good articles about ADT plus abiterone w/ prednisone. Anyone else had too harsh side effects from docetaxel and had to choose a different option?

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Evans71720 profile image
Evans71720
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11 Replies
tango65 profile image
tango65

There is not difference in outcome between docetaxel and abiraterone in your clinical condition. You should discuss to start abiraterone plus prednisone ASAP.

ncbi.nlm.nih.gov/pubmed/295...

Tall_Allen profile image
Tall_Allen

Here is a discussion of your options:

pcnrv.blogspot.com/2017/06/...

AlanMeyer profile image
AlanMeyer

I had a friend who almost died after his first docetaxel treatment. Other men do just fine. Most seem to be somewhere in between. Zytiga is an excellent alternative, as tango65's and Tall_Allen's citations show.

tom67inMA profile image
tom67inMA

How allergic are you? Five minutes into my first round I had a reaction and they had to stop the infusion, put me on oxygen, and inject hydro cortisone. They later resumed the infusion to completion at a lower rate. A week later I developed phlebitis at the injection site.

Round two I had no such problems. Not sure if your reaction was similar to mine, but if it was then there's a chance your body just might not be used to docetaxel yet.

Evans71720 profile image
Evans71720 in reply totom67inMA

Besides the usual other minor side effects the reactions with my skin has been the primary concern. I had the extreme red rash on my face that looked similar to a worst case sun burn. But I also developed numerous red itchy dots all over. The MO was concerned that another cycle of docetaxel could effect my respiratory system. I've also read about numerous patients that continued and developed deep erosions similar to staph infection on these "dots" that have popped up all over. My MO has mentioned some other oral administered chemo that may be an option. But I'm thinking my best chances for extended survival are with arbiraterone w steroid.

tom67inMA profile image
tom67inMA in reply toEvans71720

That does sound scary, and more severe than my experience.

Stegosaurus37 profile image
Stegosaurus37

I'm not surprised. Checking for allergic reaction is something I think all oncologists should do before starting docetaxel. Docetaxel is a derivative of the yew tree and allergies to yew products are not uncommon. I have a friend who makes English wood longbows. Yew wood is the gold standard for those bows but he can't use that because he is allergic to yew. Fortunately Osage orange wood also makes excellent longbows, so he's a happy camper.

monte1111 profile image
monte1111 in reply toStegosaurus37

You of course know that we all are now wondering if a derivative of the Osage orange wood would be a new treatment for cancer. I really need to trace the history of the yew tree to anti cancer drugs. I've got all kinds of trees in my back yard. Do the drugs always have to come from England or the Amazon. And I guess they are destroying the Amazon -- so there goes the next generation of cancer drugs. What are the odds that my next drugs will be on the $4.00 Walmart list? So many questions, so little time.

j-o-h-n profile image
j-o-h-n in reply tomonte1111

Yew can get them ON Amazon.

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 01/09/2019 6:07 PM EST

Bebby1 profile image
Bebby1

Thanks for this

Husband unable to cope with chemo

HospitAlised five times with severe infection

Now will commence enzalutamide

Bony Mets in spine troublesome at intervals

On opiates low dose)

If severe pain again radiotherapy for pain relief

“ spot welding”

All the best

Evans71720 profile image
Evans71720

Finally cleared insurance to begin abiraterone acetate today.......hopefully the side effects will be minimal. As with most I've read there's mixed some respond and cope well and others have bad experiences. Hope the enzalutamide will work great for you guys

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