Prolia / xgeva

[michael00]

Does anyone know the difference between prolia and xgeva?

[ctarleton]

"The targeted therapy Prolia (chemical name: denosumab) is approved by the U.S. FDA to treat postmenopausal women diagnosed with osteoporosis who are at high risk of breaking a bone or who can't take or haven't gotten any benefits from other osteoporosis treatments. Prolia is given as an injection under the skin once every 6 months."

"The targeted therapy Xgeva (chemical name: denosumab) is approved by the U.S. FDA to reduce the risk of bone complications and bone pain caused by advanced-stage breast cancer (and metastatic to bone prostate cancer) that has spread to the bone. Xgeva is given as an injection under the skin every 4 weeks."

"While Prolia and Xgeva are made of the same chemical components, each is used for a different purpose."

Men with advanced prostate cancer metastatic to bones may also be given the drug Zometa (zolendronic acid) by periodic IV by their medical oncologist. Ask your oncologist what option might be considered for you if you have significant confirmed bone mets.

Charles

[michael00 in reply to ctarleton]

Thank you

[tango65]

The dose is different and the indications are also different. Prolia is used to treat osteoporosis and Xgeva to reduce risk of bone events in PC and I assume to help with the osteopenia caused by ADT..

Each 1 mL single-use prefilled syringe of Prolia contains 60 mg denosumab (60 mg/mL solution), 4.7% sorbitol, 17 mM acetate, 0.01% polysorbate 20, Water for Injection (USP), and sodium hydroxide to a pH of 5.2.

Each single-dosevial of Xgeva contains 120mg denosumab, acetate (18mM), polysorbate 20 (0.01%), sorbitol (4.6%), Water for Injection (USP), and sodium hydroxide to a pH of 5.2.

[michael00 in reply to tango65]

Thank you

[Magnus1964]

Xgeva is much more concentrated then prolia. At least that is what my Uro told me.

[michael00 in reply to Magnus1964]

Thank you