Xgeva frequency ?

[JazzMan42]

My latest bone scan on April 8, 2019, showed T-scores as follows:

Lumbar spine (-2.4)

Left hip (-2.2)

Right hip (-2.0)

Right femoral neck (-2.6)

My understanding of these scores is that the first 4 scores shows osteopenia and the last one shows osteoporosis.

My local MO has put me on Xgeva on a three month rotation. I recently had a consult with a PCa specialist at OHSU in Portland, Oregon, and she recommended Xgeva at 60 mg doses every 6 months. I will see my MO at the end of this month and will see if he agrees with the 6 month rotation. Do any of my brothers on this site have any suggestions?

[Tall_Allen]

Yes, add Celebrex. It probably works as well with Xgeva as with Zometa. Show this link to your MO. The combination increased survival by 22%:

ascopubs.org/doi/full/10.12...

[JazzMan42 in reply to Tall_Allen]

TA, I tried to read the study you cited but could find no findings that adding celebrex to xgeva would increase survival. Clearly, I am not conversant with the jargon used in these studies. Would you mind quoting the part of the study that shows increased survival? Thanks.

[Tall_Allen in reply to JazzMan42]

It's about adding Celebrex to Zometa. I'm guessing it would work just as well with Xgeva. "Preplanned subgroup analyses in men with metastatic disease showed a hazard ratio of 0.78 (95% CI, 0.62 to 0.98; P = .033) for SOC + ZA + Cel." The hazard ratio of 0.78 means a 22% increase in survival.

[Magnus1964]

I have been receiving Xgeva 120 MG/1.7ML - every 4 weeks.

[Cheerr in reply to Magnus1964]

Hi Magnus,

Have you faced any side effects taking 120 mg every month?

Our doctor has recommended the same dose every 4 weeks.

However I see a lot of people here take it once in 3 months or 6. (So I’m a bit confused)...

[Magnus1964 in reply to Cheerr]

I have not had any side effects to Xgeva. But I can see how some might. Xgeva I have been told is a very strong Prolia. Some have experienced difficulties with Prolia. My wife is now trying to decide if she should take Prolia.

[Cheerr in reply to Magnus1964]

Nice to know you had no side effects.

Have you ever considered adding Celebrex along with it?

[Magnus1964 in reply to Cheerr]

My research doctor did not mention Celebrex. I will have to do some research on this.

[Break60 in reply to Magnus1964]

I was doing the same for quite awhile after bone mets but after my bone density scan came out normal I switched to same dose at three months . I may move to six months. I’ve been on200 mg celecoxib for many years before PCa.

[Magnus1964 in reply to Break60]

My research doctor didn't mention anything about cutting back. I'll have to ask about that.

[Break60 in reply to Break60]

I cut back at the recommendation of my urologist. I was on celebrex ( celecoxib) for arthritis many years before I found I had PCa.

[erjlg3]

Doctors told my husband his bones miraculously healed with the Xgeva. After many years on it he graduated to every 6 months about a year ago. Oh... he was and continue's to take Celebrex.

[Cheerr in reply to erjlg3]

Hello,

Good news!!

Did the doctor recommend Celebrex as well? Or was this a self made choice?

Was he on 120 mg every month before he moved to every 6 months? If yes whats the Celebrex dose to be taken along?

[erjlg3 in reply to Cheerr]

Dr. Myers put him on both. Celebrex for pain and for the benefit of helping with the Celebrex.

I'm so sorry. I don't remember the dosages. I think Celebrex is 200mg a day.

Wishin all good for you

[Break60 in reply to Cheerr]

Standard dose is 200mg daily

[j-o-h-n]

Celebrex good times

youtube.com/watch?v=3GwjfUF...(Not working as expected?)

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 08/09/2019 5:31 PM DST

[51na1a]

6 month intervals recommended for me as well.

Same dosage.

Current on lupron (monthly), Zytiga, prednisone (twice a day); now Xgeva for bone loss.

[JazzMan42 in reply to 51na1a]

Thanks-looks we are on the same path except my doses are Lupron every 3 months, Zytiga at 750mg daily, and one prednisone 5mg daily. My MO says he will shift me to Xgeva at 6 month intervals.