Vitamin D & PCa. A collaborative analysis of individual participant data from 19 prospective studies.

[pjoshea13]

New study.

66 authors from 52 institutions.

"The absence of an association of vitamin D with aggressive disease does not support the hypothesis that vitamin D deficiency increases prostate cancer risk. Rather, the association of high circulating 25(OH)D concentration with a higher risk of non-aggressive prostate cancer may be influenced by detection bias."

ncbi.nlm.nih.gov/pubmed/304...

-Patrick

[henukit]

Is the horse dead yet?

[pjoshea13 in reply to henukit]

PCa horses never seem to die. -Patrick

[monte1111]

Whoa Nellie! I read those abstracts and at the end wonder what the hell they were blah blahing about. Seems like this was an inconclusive study of a lot of other inconclusive studies. To D or not to D. If I don't my bones will break, if I do I "may" be promoting the cancer. So like everything else in life I have decided to compromise and just take one a week instead of one a day. Then, maybe my bones will just bend and the cancer will be reduced to screaming "Feed me, feed me!".

[pjoshea13 in reply to monte1111]

So far as I know, there are no studies showing increased mortality - quite the reverse.

& the new study attributes risk of occurrence to detection bias.

I cited a two-part study where a U-shaped risk was reported for occurrence, but a survival benefit was seen. i.e. in the same population!

At this point, my focus is on survival.

Incidentally, Holick (I believe) warned about eratic dosing. Seems that this might decrease availabilty to peripheral tissue, as it does when there are low levels. Better to take the same dose every day.

-Patrick

[j-o-h-n in reply to pjoshea13]

"D"elema: "D"more or "D"less?

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 11/16/2018 5:55 PM EST