Antiandrogen monotherapy to ward off the side effects of adt and increase overall survival

[rococo]

How many members have antiandrogen monotherapy without adt and with or without proscar or avodart added at some point during their course of treatment. I have noted an increase in overall survival in some of these patients

[cesanon]

What's "antiandrogen monotherapy"

[rococo in reply to cesanon]

It's done mostly in Europe with 150mg of casodex to block the testosterone from feeding the cancer. In usa mostly used on older men with just psa reccurrence thus eliminating the side effects of adt which can be tough on men over 80. Rocco

[cesanon in reply to rococo]

That sounds like androgen deprivation therapy using only one anti-androgen drug.

Am I missing something here?

[teamkv]

I am having all kinds of thoughts on this but however nothing to answer your question...

[Tall_Allen]

"I have noted an increase in overall survival in some of these patients" Do you have a reference to share or is this an anecdotal observation?

[rococo in reply to Tall_Allen]

Unfortunately anecdotal. Wish there were clinical studies on this paradigm shift. Most of the early studies wer done with flutamide till casodex came along and the studies stopped as the patent for these drugs expired. I know there are many on this who tried this therapy and had good results, I for one with 7+ years on casodex but I must stress if you have that very agg. pc casodex may feed the cancer. Best to all. Rocco

[rococo in reply to rococo]

Sorry I left out avodart which was taken with the casodex

[herb1]

Hi rococo: As I recall, one of the problems with casodex high dose (150 mg/day) was liver issues. It needs to be considered, at least, if exploring this avenue. And, with the advent of Abiratarone and Xytiga, these have probably replaced high dose casodex for most. Side effects to them? Of course!

[Notsdr]

I have been on intermittent low dose 50mg bicalutamide monotherapy for more than 3 1/2 years (DX 2008, Age 52, PSA 136, pT3bNOMX, GS 8, RRP, SRT, BLPLND). PSA now ranges between 20 and 70. I have not yet used a GHRH or LHRH antagonist or agonist.