The "supper-sleep interval".

[pjoshea13]

New Spanish study below.

On the face of it, we are better off not eating close to bedtime. & perhaps not eating the heaviest meal of the day in the evening.

But how to factor in the eating patterns of Spain in this study, where some still take a siesta & may enjoy a plate of gambas al ajillo at 10 pm?

Anyway: "Compared with subjects sleeping immediately after supper, those sleeping two or more hours after supper had a" 26% reduction in PCa risk.

-Patrick

ncbi.nlm.nih.gov/pubmed/300...

Int J Cancer. 2018 Jul 17. doi: 10.1002/ijc.31649. [Epub ahead of print]

Effect of mistimed eating patterns on breast and prostate cancer risk (MCC-Spain Study).

Kogevinas M1,2,3,4, Espinosa A1,2,3,4, Castelló A4,5,6, Gómez-Acebo I4,7, Guevara M4,8, Martin V4,9, Amiano P4,10, Alguacil J4,11, Peiro R4,12, Moreno V4,13,14, Costas L15, Fernández-Tardón G4,16, Jimenez JJ4,17, Marcos-Gragera R18, Perez-Gomez B4,5,19, Llorca J4,7, Moreno-Iribas C8, Fernández-Villa T9, Oribe M10, Aragones N4,20, Papantoniou K1,21, Pollán M4,5, Castano-Vinyals G1,2,3,4, Romaguera D1,22,23.

Author information

1

ISGlobal, Barcelona, Spain.

2

IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.

3

Universitat Pompeu Fabra (UPF), Barcelona, Spain.

4

CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.

5

Environmental and Cancer Epidemiology Unit, National Center of Epidemiology, Instituto de Salud Carlos III, Madrid, Spain.

6

Faculty of Medicine, University of Alcalá, Madrid, Spain.

7

Universidad de Cantabria - IDIVAL, Santander, Spain.

8

Public Health Institute of Navarra, IdiSNA, Pamplona, Spain.

9

Grupo de Investigación en Interacciones Gen-Ambiente y Salud, Instituto de Biomedicina (IBIOMED), Universidad de León, León, Spain.

10

Public Health Division of Gipuzkoa, BioDonostia Research Institute, San Sebastian, Spain.

11

Centro de Investigación en Recursos Naturales, Salud, y Medio Ambiente (RENSMA), Universidad de Huelva, Huelva, Spain.

12

Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana FISABIO - Salud Pública, Valencia, Spain.

13

IDIBELL-Catalan Institute of Oncology, L'Hospitalet de Llobregat, Catalonia, Spain.

14

Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain.

15

Unit of Molecular Epidemiology and Genetics in Infections and Cancer, Cancer Epidemiology Research Programme, IDIBELL, Catalan Institute of Oncology, Barcelona, Spain.

16

Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Asturias, Spain.

17

Instituto de Investigación Biosanitaria de Granada (ibs.GRANADA), Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain.

18

Epidemiology Unit and Girona Cancer Registry, Oncology Coordination Plan, Department of Health, Autonomous Government of Catalonia, Catalan Institute of Oncology, Girona Biomedical Research Institute (IdiBGi), Girona, Spain.

19

Cardiovascular & Metabolic Diseases Unit, National Centre for Epidemiology, Carlos III Institute of Health, Madrid, Spain.

20

Public Health Division, Department of Health, Epidemiology Section, Madrid, Spain.

21

Department of Epidemiology, Center of Public Health, Medical University of Vienna, Vienna, Austria.

22

Instituto de Investigación Sanitaria Illes Balears (IdISBa), Hospital Universitari Son Espases, Palma de Mallorca, Spain.

23

CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Madrid, Spain.

Abstract

Modern life involves mistimed sleeping and eating patterns that in experimental studies are associated with adverse health effects. We assessed whether timing of meals is associated with breast and prostate cancer risk taking into account lifestyle and chronotype, a characteristic correlating with preference for morning or evening activity. We conducted a population-based case-control study in Spain, 2008-2013. In this analysis we included 621 cases of prostate and 1,205 of breast cancer and 872 male and 1,321 female population controls who had never worked night shift. Subjects were interviewed on timing of meals, sleep and chronotype and completed a Food Frequency Questionaire. Adherence to the World Cancer Research Fund/American Institute of Cancer Research recommendations for cancer prevention was examined. Compared with subjects sleeping immediately after supper, those sleeping two or more hours after supper had a 20% reduction in cancer risk for breast and prostate cancer combined (adjusted Odds Ratio [OR] = 0.80, 95%CI 0.67-0.96) and in each cancer individually (prostate cancer OR = 0.74, 0.55-0.99; breast cancer OR = 0.84, 0.67-1.06). A similar protection was observed in subjects having supper before 9 pm compared with supper after 10 pm. The effect of longer supper-sleep interval was more pronounced among subjects adhering to cancer prevention recommendations (OR both cancers= 0.65, 0.44-0.97) and in morning types (OR both cancers = 0.66, 0.49-0.90). Adherence to diurnal eating patterns and specifically a long interval between last meal and sleep are associated with a lower cancer risk, stressing the importance of evaluating timing in studies on diet and cancer.

KEYWORDS:

breast cancer; circadian disruption; diet; prostate cancer

PMID: 30016830 DOI: 10.1002/ijc.31649

[cesanon]

""Compared with subjects sleeping immediately after supper, those sleeping two or more hours after supper had a" 26% reduction in PCa risk."

Wow

[DonUSNA73]

Maybe it wasn’t supper-sleep interval but total time between supper and breakfast which may not have been measured. And what about pollo al ajillo vice gambas?

[Kuanyin in reply to DonUSNA73]

Don, I think you are, possibly, closer to the most accurate explanation for this phenomenon. For many years, I have seldom (unless on vacation), eaten my dinner any later than 7:00 PM (usually between 6-7). Normally, I don't eat breakfast until after I have done my morning exercises, with the exception of workouts at a gym. Breakfast is at 8:00 AM which means that 13 hours have elapsed between dinner and breakfast. I have read somewhere that this time interval could be considered as a mini-fast. Let's not forget that the meaning of "breakfast" means breaking the fast of the prior night. A mini-fast could result in an inhibition of IGF-1R signaling which might affect tumor growth. Good call.

K.

[pjoshea13 in reply to Kuanyin]

Coincidentally, "a new book, “The Circadian Code,” by Satchin Panda, a professor at the Salk Institute and an expert on circadian rhythms research" was reviewed in the NY Times yesterday:

nytimes.com/2018/07/24/well...

"Dr. Panda argues that people improve their metabolic health when they eat their meals in a daily 8- to 10-hour window ..."

-Patrick

[j-o-h-n]

and a side order of Mujeres del día..... gracias amigo.

Good Luck and Good Health.

j-o-h-n Saturday 07/21/2018 12:12 PM EDT

[Stegosaurus37]

Did they find a causal link or is this just happenstance? Eating patterns vary like crazy all over the world and even within countries. My mother-in-law cannot understand why I have not been struck down by lightning for the blasphemy of ignoring breakfast ("the most important meal of the day"). Well, I've ignored breakfast for the last 55 years and, aside from the cancer I'm still as healthy as a horse and if you want to maintain that my cancer is a result of ignoring breakfast, the burden of proof is on you

Coincidence is not causation.

[Hidden]

Let's see, my MO tells me I will be carbon within 18-24 months. I personally feel that I should (and will) eat what I want, when I want. No disrespect to the poster intended.

[j-o-h-n in reply to Hidden]

Carbon? My MO said I'll be 24 karat gold if I continue to eat chocolate chip ice cream...

Good Luck and Good Health.

j-o-h-n Saturday 07/21/2018 7:00 PM EDT