Conclusions: In this meta-analysis, moderate wine consumption did not impact the risk of PCa. Interestingly, regarding the type of wine, moderate consumption of white wine increased the risk of PCa, whereas moderate consumption of red wine had a protective effect. Further analyses are needed to assess the differential molecular effect of white and red wine conferring their impact on PCa risk.
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Kidding aside, the finding of protective effects from red wine but not white wine suggests that Resveratrol, found in the skins of grapes, may be responsible. Red wine is fermented on the skins and has resveratrol, white wine is fermented after the pressed juice is separated from the skins.
I take a Resveratrol supplement. It's an unstable compound so you have to be careful about which brand you choose. The 100 mg capsule I take daily has as much resveratrol as about 100 glasses of good red wine.
NFI, I did my research and decided this brand had the best documentation, purity, and packaging to preserve the delicate molecule.
I have to admit I have my reservation on Resveratrol. It has been a subject of heated debate on this forum. It's yet another hormetic polyphenol with strange dose-response curve. It's generally agreed (my understanding) that at "lower" dosage - e.g. moderate red wine drinking - it benefits cadiovascular functions, and is chemopreventive. At "high" doses, it's harmful to your heart, but does inhibit the growth of cancer cells (not limited to PCa). So as a cancer patient it's a bit of dilemma: anti-oxidants inhibit ROS (which is not good for cancer patients), however, they have so many other benefits all over your body.
The product you mentioned (longevinex) is interesting because it's been shown that it is NOT hormetic, and does NOT have negative cardiovascular effect. I need to understand its mechanism of action a little better.
Everyone has to evaluate the information and make the best decision they can. EVERY drug, supplement, surgical procedure, all of them have a chance of helping you, and a chance of hurting you. Resveratrol is no different.
That study used truly enormous doses of resveratrol, up to 100 mg/kg. My dose is closer to 1 mg/kg. Based on the research that I evaluated, which was in humans (we're too good at both causing and curing cancer in mice) I decided that Longevinex was more likely to help me.
Many studies have shown a therapeutic window, this is not uncommon in many drugs and supplements. More is not always better. The evidence for resveratrol is pretty clear that too much is likely to do more harm than good, but a little (like a few glasses of red wine) definitely help. The best spot is probably somewhere in between.
Longevinex is one of very few brands that has conducted their own research; the website has several discussions of how they set the recommended dose.
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