How many are on docetaxel and has it worked
Docetaxel : How many are on docetaxel... - Advanced Prostate...
Docetaxel
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wongle
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It took my psa from 850 to 0.07. In the last 3.5 years using just Lupron, my psa is currently 0.30. It worked wonders for me. Docetaxel isn't the monster that it's made out to be.
wongle in reply to
Is lupron like docetaxel Bill and hubby has bone mets is aggressive he is hoping to have another 8 sessions
Thank you by the way Bill I apologise for my ignorance lol
in reply to wongle
They are dofferent ways to attack the cancer. Lupron deprives most the cancer cells of the male hormones it needs to reproduce and chemotherapy kills the full spectrum of cancer cells, inclduing the ones that don't need the hormones. Together they make an even better treatment than either would by itself.
Two major trials proved that: CHAARTED and STAMPEDE. You can do a search on those to get more information.
I did chemo a year ago and it was not bad at all. It got my PSA down from 463 to 0.19. I would recommend it.
wongle in reply to
Thanks Gregg I understand now Steve still has the three monthly injections but chemo as well they said 16 months without chemo 19 with but how can they say that
JPOM in reply to
care to share what was that chemo? man, why would you mention something like that and NOT say what it was???
in reply to wongle
Lupron and Docetaxel are not alike. gregg57 explained the difference quite well above. Docetaxel did a nice job resolving my bone mets and completely cured the cancer in my lymph nodes.
Lastly , you NEVER have to apologize for any reason here, we are all in this together and learn from one another. good luck.
wongle in reply to
Yep your right Bill x
Very interested in your query asi too am about to start on docetaxel. I had an enlarged Prostate and was on Tamsulosin for 18 months when I went to New Zealand for three months. I had intense back pain one month into the vacation. A visit to the GP, then Ultrasound and CatScan all within one week and I was diagnosed with Prostate cancer that had spread to five vertebrate, whilst on vacation in New Zealand. I opted to start immediate treatment in NZ. Five days of consecutive treatments of Radiation for the bone cancer and an ZOLADEX injection. No side effects from the radiation, but intense hot flashes from the ZOLADEX injection, up to three an hour (20 in one 24 hour period), which I find debilitating. Now back in BC (it took 8 weeks to see Specialists) I have just had a full body scan and further PSA/Blood test. Prior to NZ treatments my PSA was 500 with Gleeson 5+4 . Following NZ treatments PSA dropped to 80 . Now my Plan calls for further Radiation, followed by Docetaxel Chemotherapy for 5 months, followed by Aberitone/ Prednisone . Reading the side effects of Docetaxel scares the daylights out of me!
My husbands psa 4300 at diagnosis. Lupron and docetaxel now psa 6. I read the more mets you have the more you should lean towards docetaxel. Husband in clinical trial with possible drug odm. He is up and active after surviving chemo. No pain and able to lead fairly normal life. Diagnosed aug 2017. Be sure to have top specialists admister chemo.
Yep Steve is on prednisone and docetaxel but this PSA shite pardon my French his highest was 144 went down to 7 now 30 and he has aggressive prostate cancer
The more I read the PSA and gleason score means nothing every prostate cancer is different for every man this is the problem it's individual that's why it's so nasty not like other cancers
PSA and Gleason combined with PSMA and MRI scanning... it's all we got, until the genomic component become more sophisticated. the problem with GL is that yes, it identifies how aggressive the PCa cells are... but only for the samples that are examined! what about the rest of the gland? there're two diagrams explaining what the pathologist sees when looking at biopsy cores - here's one: prostatecancerfree.org/pros... - the other i have as a .jpg - not sure the URL it came from
in reply to BartonKen
Docetaxel isn't nearly as bad as they make it out to be. A guy on this site ran 6-10 miles in 80 degree heat while going through his chemo treatment. The stuff is a major life extender.
Don't be scared I just can't believe yes America is so far in front of England but we don't have to pay for treatment but my hubby was a policeman who was around with the Moor murders and had to listen to the torture tapes and pays his taxes he has had two treatments of docetaxel and is doing really well still has his hair felt a bit sick toilet a few times lol tired but he has always been tired but walking better eating better are you also going to have prednisone at the same time
I just finished my 11th treatment using docetaxel along with Lupron. The Chemo initially worked for about 4 months, now my PSA is rising again. According to my doctor, I'll probably have a few more treatments with docetaxel then switch to Cabazitaxel. I've found that the side effects are tolerable. I try to stay on top of them so that I can minimize the impact.
Hi are you in America x
Yes, I receive my treatments at the Utah Cancer Clinic in Salt Lake City Utah.
in reply to dlestercarlson
Do you happen to see Dr. Kathleen A. Cooney ? She is one of the best. She was my MO while at university of Michigan.
I have no idea. I did them together as an intial treatment. I assume most of the PSA drop was due to ADT. whether and how much was the effect of the chemo, I can't say. It was well-tolerated however.
wongle in reply to
as I said it's a bad cancer that creeps round one personthen changes for another but I still believe the gleason score is rubbish and the PSA levels my Steve has aggressive prostate cancer his PSA at the highest was only 144 but had gone from his prostate to lymph nodes and vesicular tract and now after 3 years it's now in his spine collar bone ribs but his PSA is only 30
Docetaxel (Taxotere) plus lupron worked for me, Lupron dropped PSA to 6.8. With Taxotere down to 0.140. Now 4 months and still healing from severe side effects. #9 cycle darned near killed me. (see my other posts). All of us handle chemo. differently, but hit it hard and hit it early. Good luck. No more Lupron- Orchiectomy 10 days ago.
doug- AZ-Flag.
Hello, I was hit with Stage IV prostate cancer in 01/2015, GL 7(4+3), PSA at 840. Started ADT (Lupron/Casodex) and 2 weeks later had Taxotere. After six sessions, the PSA was still in teens and MedOnc spoke with a tumor board and none would say to give more. He left it up to me he said "I'll give you more chemos until the #s plateau or you say to stop".
We did nine more for a total of 15 - last one on 12/17/15. PSA got to 0.7 - started Metformin and got to nadir in 08/16 of 0.2
theloopnewspaper.com/story/...
My best to y'all
My side effects from Docetaxel:
Extreme fatigue for first week after infusion, extreme flu like joint and bone pain (partially resolved with Claritin), nasty rash on my hands and arms, partial loss of feeling in fingers and toes, fingernails turned yellow and brown, loss of taste, constipation (resolved with daily probiotic pill), watery eyes, dry unproductive cough, hair loss.
Never had nausea, but some people do. Would I do it again? In a heartbeat. Cancer in lymph nodes is no longer detectable on scans. PSA went to undetectable It wasn’t fun, but it can be tolerated. It’s been six weeks since I stopped, and all side effects are resolved or starting to resolve.
Good luck!
Hi Canoehead,
Well done! I had 6 cycles of Chemo(Docetexal) which I completed 3 weeks ago from today. But now on my 25th day after my last chemo, noticed having swollen legs around my ankles (both legs). Been reading up and many said this is part of the chemo treatment and was advised to raise my legs often and it will soon disappear. I am wondering if any of the brothers went through this after their chemo cycles. Feeling anxious about this condition.
My very best to all!
Haniff
Sore feet,toes burn, swollen ankles,shooting pains . 12 weeks after #9 chemo. May be related to Xtandi. Doc says it's a combination of the two. May get better may not, just have to wait and see for me. Good luck with yours. Hope it doesn't hang on as long for you. Sounds like yours isn't as sever as mine, so should subside on its own before long. Good luck and carry on with the battle.
Doug-AZ
Thanks Shooter1.
Appreciate it and frankly, love your profile name 
Take care
Haniff
Shooter1 came about from NMLRA national meets here in AZ. 3 of last 4 years took grandson and only did matches he wanted (primitive pre-1840 clothing and gear). I didn't place in as many matches or aggregates, but had a ball. Couldn't make it this year. Just after chemo #9 and I couldn't lift a rifle,see the sights, set up camp or walk. Not so good a condition for National shooting competition. In a new fight/competition now. Maybe next year will be my 12th year to compete.
Doug
PS. Great people here but not enjoying new fight.
Hi Haniff,
I had the same thing about the same time, after the chemo. I’d wake in the morning my legs were almost normal and 10 mins of walking around, my ankles would swell up. No serious pain as I recall. I’d try and rest with my legs elevated because I was still recovering from the ass whooping it gave me. I also had serious joint pain in my legs and hips in the end and following chemo. That was August of 2017, all those are long gone and the chemo is the only thing that really worked. I think you just need to give it a little more time as hard as that can be. I remember him telling me six weeks to flush before any procedure could be scheduled when I suggested surgery vs taking Lupron the rest of my life, knowing Zytiga, Xtandi, and who knows what are in my future. Good Luck
Thanks for the info and motivation, appreciate it.
Take care and cheers.
Haniff
Thanks one and all. It’s helpful to have the positive replies.
Stage 4 at dx age 54 in july 2017. I had extensive mets through the spine and lymph nodes. Did lupron plus chemo as my initial treatment. I ended up doing 10 rounds. At the end had 0.01 psa and all visible mets resolved. It was easy through round 8. 9 and 10 were tough. Its been 3 months after and my psa is still 0.01 and my energy continues to rebound.
My pc was very aggressive as I had mets in my vertebra. I had 10 cycles of docetaxel along with lupron. Now after 18 months, my psa is 0.08 and stable from last 6 months.
Initial diagnosis in 2015. In Dec 2017 was castrate resistant wth mets in liver but no boney mets. PSA 47.
Started docetaxal 29 Dec, and just finished 7th dose. PSA after Cycle 6 is 1.8. So docetaxal is working, for how long it works is the big question. Will have more scans after Cycle 10.
In retrospect, it would have been better to have had chemo when I started ADT, as several men responding in this thread have done.
Good Saturday Morning wongle,
Had 6 cycles of Docetaxel/Carboplatin chemo which dropped PSA from 10.8 to .4! Better result is that cancer cells were reset and a rechallenge with Xtandi is working for me.
Best wishes. Never Give In.
Mark, Atlanta
Mark, Are you saying that You had previously failed xtandi, but after 6 rounds of docetaxol/carbo you are having a successful rechallenge with xtandi. This is such good news to me and inspires a lot of hope for me and others of what we can do after chemo. Thanks for posting.
Yes, Dan59! I initially took Xtandi back in 2015-2016 under the care of Dr. Snuffy Myers, and after about 12 months it failed. I had previously taken Zytiga + Prednisone for about 18 months (please see bio).
Had 6 cycles of Docetaxel/Carboplatin chemo from 9/17-1/18 after PSA rise and mets found in liver.
Last chemo was 1/9/18 and restarted Xtandi on 3/19/18 while on chemo break. PSA dropped from 1.3 to .7 and has held at .7 through blood test of 5/10/18. Just as important, the liver lesions have gotten smaller with fewer of them.
Take away is, that for me, Xtandi is working for a second time. It is a miracle. I guess this is somewhat like BAT response.
Best wishes. Never Give In.
Mark, Atlanta
Right on Mark, There are studies that show that chemo can reverse the arv7 in patients , it was just over 50% that this happened to, I too failed xtandi a few years ago, and have been on chemo pretty much since then. I had always planned to return to zytiga or xtandi and take a chemo break My MO said that it would never work,In the past year with these new studies we find the arv7 can be reversed, and sometimes we can respond again. I am so happy for you having such a good response, I pray it last a long time.
Dan
Daddysdaughter posted in the last few days that Her Dad is having a very nice psa response after 13 days of zytiga after failing xtandi , and docetaxol/carboplatin
Hi Dan,
One thing you learn in this battle is that we are all different--in the way we started; in the treatment paths; and in the responses to treatments. Whenever I ask my Med Onc the "how much time have I got left" question, I remind myself that none of us are the same.
Hope you have a wonderful Mother's Day celebration planned for someone special!
Mark
My husband was dx aug 2014 with Gleason 9, psa 70, and bone Mets. Feel fortunate to have started with Lupron and dosetaxel at the start. Had some great trips and time together since then . Minimal se from chemo. Psa down to .39. Psa started to climb. Did provenge with minimal se. Now just completed cabataxel and xtandi tril to remain on xtandi. This last round has had greatest fatigue, depression. BUT all in all, we had have some great times with each other, and others with other types chronic diseases have had it much harder. So glad to have started after chaarted. He has maintained walking and some gym thruout.
I'm so glad this has started a good response I am really interested that after docetaxel some of our men have been put back on the tablets x good luck to all of us xx
Had my 6th docetaxel treatment a week ago. It doesn’t appear to doing much. Psa was 10 when I started and it’s been up and down. Last week it was 10.5. It seems like it’s just holding back the tide for now.
After 19 docetaxel treatments that did not drop the PSA at nadir more than 39%, we are hoping that Xtandi that did work well for two years will work again. It certainly would be easier on the body than cabazitaxel. Tomorrow's scans we pray will show the new growth in an area that can be safely biopsied.
Doing infusions every 3 weeks. Had 1st one. Oncology said it does not work well on bones but works good on soft tissue tumors anywhere. I already had Radium 223 for bone, now on Chemo for the tumors that showed on my pelvic MRIs. 1 infusion so far and all my pain is gone already. Logically, I think If the soft tumors wrapped around and growing on my pelvic bones (as shown on my MRI), killing those should help my bones too. Pain that went away indicates that this might be happening. Will check my numbers next week.
Side effects very minimal so far, so I am lucky.
Told to wear a mask if I go out in public and dont eat restaurant salads. Wash hands a lot. Dont go out in crowds within first 16 days after an infusion, because that is when you are at risk for infection. We want to start ballroom dancing again on Saturday nights perhaps within a few days BEFORE an infusion when my immune should be OK, but I will look strange wearing a mask over my mouth. Have good energy.
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