Bicalutamide vrs zytiga

[Bigpike]

Currently on Bicalutamide looking to press substituting zytiga for Bicalutamide, looking for best evidence to share with doctors, and to learn. Diagnosed 9/17, PSA 147, bones. Current PSA 0.1 with Lupron + Bicalutamide. Feedback, including side effect experience is appreciated.

[Magnus1964]

I realize everyone is different and prostate cancer is a cluster of diseases. I started out on Caxodex and got 5 years out of it with a PSA of less than 1. I guess I don't know the real difference between Casodex and Zytiga or xtandi other than the hugh cost. Is this a case of big pharma pushing the more expensive drugs before the patents expire, or is there a difference in one cancer vs another? Is zytiga and xtandi used for more aggressive cancers? This is a crap-shoot.

[Tall_Allen]

That is a great response to the hormone therapy you are using. Both the STAMPEDE study and the LATITUDE study showed that early use of Zytiga extended survival by quite a bit. Here's an article about it:

pcnrv.blogspot.com/2017/06/...

[milto27xabc]

I was on Lupron and Casodex for 10 years--when PSA rose to 13 stopped casodex and started Zitiga Oct 15/18. Psa 0.1--always had hot flushes--some fatique which got much worse with Zitiga--no free passes with Pca treatment --but great Psa. have Lymph node involvement since 2007--no radiation and Onc says too late now?

[Hidden]

Lupron shuts down Testosterone from the testes. Bicalutamide is an anti-androgen that blocks testosterone from the androgen receptors on the cancer cell. Zytiga shuts down Testosterone from more sources than Lupron. If your PSA is undetectable, why change? After my cancer recurred in 2011 (surgery and radiation in 2009), I went on Lupron/Casodex for 3 years with PSA undetectable. When PSA started rising, I switched to Lupron/Nilutamide and PSA went undetectable. After Provenge in 2014, I dropped Lupron but kept Nilutamide. PSA is still undetectable today. Everyone is different and my advise is to find the combination of drugs that keeps your PSA undetectable with the least impact on quality of life.

[rmiles1229]

Began Lupron in April 2015 after chemical recurrence of cancer 4 months after prostatectomy. Since April 1, 2015, PSA has been below detectable limits. I don't like the side effects of Lupron: enlarging breasts, short term memory is declining and osteopenia. In spite of the side effects, I apparently have no option but to put up with them or have the cancer return and shorten my life. To date Lupron is the only treatment I have been given.