PSA RISING AFTER ANOSOTHERAPY ATEZOLIZUNAB

[Giorgos]

I made 5 therapy sinc 8/11/17 PSA i rising 200 to 300 an 500. Dr todl me rising ca happend. I would be obliged to have information!

[Hidden]

PSA is pretty high. Have you had chemo or hormone therapy?

Is 'Atezolizumab' a trial? I have not heard of it before.

[wrando in reply to Hidden]

Atezolizumab (Anti-PD-L1 Antibody) not approved

[Dr_WHO]

Hello and welcome to the group. I am not sure what you mean by ANOSOTHERAPY ATEZOLIZUNAB. Do you have lung cancer?

In any case with your PSA so high you need to get it checked for prostate cancer. The first thing to do is have a biopsy. The sooner the better. Depending on the results you should also get s bone and CT scan to see if it has spread.

Once again, welcome to the group! You are now part of our family. We are all pulling and praying for you, especially if you are also fighting lung cancer. In any case we are with you. After all, people like us we have to stick together!

[Giorgos in reply to Dr_WHO]

2014 age 52 first routine PSA test : 35,49ng/ml + enlarge prostate.

Biopsy : ADENOCARCINOMA

Gleason score 8(5+3) + negative for mets

Hormonotherapy FIRMAGON

20/10/15 Surgical intervention. Total prostatectomy (L. Da Vinci robot assisted ), removal of seminal vesicles and lymph nodes.

Biopsy DIFERENCIATION TO NEUROENDOCRINE

Hormonotherapy ELITYRAN and chemotherapy TAXOTERE -CARBOPLATINE (4 cycles). PSA decline. After 4 cycle PSA is rising to 200 ng/ml despite 2 new cycles chemotherapy and hormonotherapy + bones mets

4/11/17 removal tumor urinary tract and pigtails for kidney dilatation

Since 8/11/17 I am in TRIAL ANOSOTHERAPY with ATEZOLINUMAB and XTANDI

PSA rising to 300

Last proposition nanoPET and nanotherapy in CHARITE Hospital Berlin Germany.

Any knowledge or experience is precious! thank you!

[Tall_Allen]

Atezolizumab (Tecentriq) is an immunotherapy. It blocks a protein on cancer cells called PD-L1 that keeps the immune system from attacking it. It is unknown whether it works on prostate cancer, and is in clinical trials. It is also uncertain that PSA is a good indicator to show if it is effective. With another immunotherapy, Provenge, PSA is often not reduced at all, yet it prolongs life.

[Melaine50]

In my case PSa is 490. Had this checked out with a series of tests t o see if my prostate cancer had metastasize also to relieve blockage in the liver and kidney. Received two injections of Firmagon to lower PSA. Taking another in couple weeks.