hang on as long as you can. help is ... - Advanced Prostate...

Advanced Prostate Cancer

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hang on as long as you can. help is on the way.

15 Replies

nature.com/articles/ncomms1...

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wifeofvet profile image
wifeofvet
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15 Replies
cfrees1 profile image
cfrees1

I found this confusing. What's the net net of this?

in reply tocfrees1

I can't believe I'm going to admit this, but, I got it by looking at the diagram. Jeez, nanobubbles, and tiny pieces of gold. Poof! Dead cell.

Joe

So, we'll be getting "Spased" some day.

timfiskwa profile image
timfiskwa

So when can I get Cancer killing nanobots?

wifeofvet profile image
wifeofvet in reply totimfiskwa

i have no idea. my husband wants to be a guinea pig.

AlanMeyer profile image
AlanMeyer

I have only a tiny fraction of the scientific knowledge that I think is needed to really understand the article, but my guess is that the article is saying something like this:

A material has been developed that, when stimulated by laser light, will emit more light at a lower frequency, and the material that does this can be made in such a way that it binds to cancer cells (because it binds to folate, which is much more common on the surface of tumor cells than healthy cells.)

The material can be used to diagnose cancer, for example by treating a blood sample with the material, shining a laser light on it, and comparing the brightness of the "spaser" outputs of the blood with that of normal blood. Circulating tumor cells would cause extra spaser light to appear.

In theory, the material can also be used to treat cancer since stimulating the nanoparticles of material with lots of laser light can cause them to heat up as they emit spaser light. The heat might kill the tumor cells that they are attached to.

However, my guess would be that we are many years away from any practical techniques for treating prostate cancer. For one thing, I don't know if there's any practical way at this time to shine sufficient laser light onto the areas with tumor cells that are not right at skin level. Diagnostic uses, or uses with skin cancer, might be available sooner, but even they would require a lot of testing just to find out how accurate the diagnostic results would be, much less how effective the treatment would be. So this scientific report is pretty strongly in the category of "basic" rather than "applied" research.

At any rate, those are my guesses about the significance of the article.

Alan

wifeofvet profile image
wifeofvet in reply toAlanMeyer

nanoparticles are so tiny they go everywhere.

Sisira profile image
Sisira

Various advanced technologies must be on the way - far or near which we are not quite sure of and this is our optimism that some day there will be a CURE for cancer.

After having seen a couple of similar articles on using Nano-technology for the effective treatment of prostate cancer, my discussions with some experts proved to me that no sufficient research or trials have so far been conducted in this field.

There is nothing wrong in anticipating new scientific developments. But we must sustain our main treatment lines and keep the decease well under control.

Sisira

wifeofvet profile image
wifeofvet in reply toSisira

this is true and is why i said ''hang on as long as you can.'' it's always ''the next best treatment.

Sisira profile image
Sisira in reply towifeofvet

Absolutely correct!

Thanks

Sisira

TheTopBanana profile image
TheTopBanana

What are the stats on these studies?

ctarleton profile image
ctarleton in reply toTheTopBanana

I'd guess that they are still largely in the basic research stages.

One of the principle authors who works at the University of Arkansas for Medical Sciences, Dr. Vladimir Zharov, has been involved with first steps in the medical application of this approach for many years. He more recently was involved in spinning out a start-up company for a device that could non-invasively monitor circulating blood to detect malaria infected cells.

asbtdc.org/portfolio/cytoas...

Similar methods have been explored to try to detect circulating tumor cells of melanoma. The end goal is to see if the use of nano-scaled lasers called Spasers might be used to detect and "zap" at nano-levels in any tagged/naturally detectable cancer cells. The path to any FDA Clinical Trials process involving prostate cancer or other majors cancers is likely still a long way off. I'd guess that there could be a world of difference between being able to "zap" passing circulating tumor cells vs. detecting and zapping very large masses of millions of cells embedded deep within the body or within bones.

Here's a link with a photo of some of the experimental hardware.

medgadget.com/2019/06/spase...

Here's a link to Dr. Zharov, including a list of some of his most recently funded research areas.

uams-triprofiles.uams.edu/p...

It would be cool if they could eventually get it to work anywhere and everywhere.

(I also keep thinking back to the campy old 1966 film Fantastic Voyage, starring Raquel Welch ... where they took an exciting journey through the human body in a miniature submarine, fighting dangerous or bad cells along the way. Good Stuff for the age I was then. Ha. Ha.)

Charles

TheTopBanana profile image
TheTopBanana in reply toctarleton

Thank you so very very much for your reply! Now I have my Saturday made out for me - trying to actually understand these studies in detail. Always exciting when something gives you hope. And haha what a movie! Everything about this sure feels science fiction, but then again, cancer could use some old times superheroes in perfect 60s haircuts (had to google the film) zapping away...

TheTopBanana profile image
TheTopBanana in reply toctarleton

Hello again! A wild shot but I emailed Mr Zharov, Vladimir P and he replied! I told him it was regarding advanced prostate cancer and he said that the trials are on pause now because of Covid19 but that mean that there IS trials even for prostate cancer!

TheTopBanana profile image
TheTopBanana in reply toTheTopBanana

He said the first study will probobly be blood cancer though.

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