Vitamin D3 Can Double The Effects of Docetaxel

[gusgold]

Here is an older study I had not seen before

Gus

vitamindwiki.com/Chemothera...

[paulofaus]

Thanks Gus, Your link didn't work for me, but I think I found the post here: vitamindwiki.com/Chemothera...

[Hidden]

Interesting. Tomasz Beer has done other studies with vitamin D. I like him.

The "choose your adventure" graphic that goes with the article seems false.

[rococo]

Extensive info on d3 but none none on the side effect of calcification of arteries and kidney stones I hope I'm controlling with 50mg of vit k2

[pjoshea13 in reply to rococo]

I wondered what the Vitamin D Council had to say about stones:

[1] vitamindcouncil.org/does-vi...

Some doctors are telling their patients that vitamin D causes kidney stones. It makes sense right? Vitamin D is involved with calcium absorption so that calcium may increase the risk for kidney stones. The theory has what we call “face validity,” which means it sounds right. However, two recent studies have found just the opposite; the lower your 25(OH)D, the higher the risk for kidney stones.

[1a] ncbi.nlm.nih.gov/pubmed/270...

[1b] ncbi.nlm.nih.gov/pubmed/264...

[2] vitamindcouncil.org/does-vi...

"The sad thing is that the prevention of kidney stone is easy; just alkalize the body by increasing the magnesium and potassium in the diet. The best way to do this is to eat foods rich in potassium and magnesium such as vegetables, fruit, seeds and nuts. In fact, over three years, those on a potassium-magnesium citrate preparation had a five-fold reduction in kidney stones."

[2a] ncbi.nlm.nih.gov/pubmed/936...

-Patrick

[rococo in reply to pjoshea13]

I usually put ph balance alkalizing greens drink with probiotics from swanson in my tea or coffee to sweeten them up a bit ans neutralize the acid somewhat.

[Dan59]

I remember when guys were in this study, and others on the HRPCA list were just doing the high dose pulsed calcitrol in pill form the day before chemo, and then one day the study was terminated for an unexplained higher percentage of deaths in the arm with the men getting docetaxol with calcitrol (vit D) ,here is the link marketwired.com/press-relea...

[gusgold in reply to Dan59]

The study I referenced was a completed study using Vitamin D3 with a conclusion....the study you referenced used a drug Asentar

[pjoshea13 in reply to Dan59]

Dan,

Calcitriol is hormonal D (1,25-D). It cannot easily/safely be given to patients. Cholecalciferol (normal D supplement) is stored as inactive calcidiol (25,D).

For PCa, we rely on the kidneys converting calcidiol to calcitriol (25-D to 1,25-D). Which is why researchers have been looking for a safe analog of calcitriol for some years (unsuccessfully).

I would not expect any problems with studies using cholecalciferol, but problems are to be expected with calcitriol.

-Patrick

[Dan59]

No,The News article you referenced was an earlier phase in the Ascent trial (DN101), It failed in phase 3 to show better Over all survival They use high dose calcitrol in both, the are the same trial , Notice how both studies referred to DN101 as the active agent used with Chemo,DN101 was high dose pulsed calcitrol taken the night before in some 30 tablets, I remember the study and in Yours was from 2002, well in 2007 when we thought they would approve it, they came out that the dn101 arm had a unexpected higher incidence of the most unfortunate of side effects, that being death, as well as decreased survival over placebo, Thus is why it is not standard of care today. See abstract below for details

Here is another abstract saying the same thing. ascopubs.org/doi/abs/10.120...

[gusgold]

No, in the trial I referenced they used Vitamin D3 and in the later trial Asentar which made the Docetaxol toxic...which proves the point that Vitamin D3 makes Docetaxol more effective but over a certain limit Docetaxol dose has to be reduced. Below is a 2010 evaluation of Vitamin D3. If I ever need Docetaxol I am taking 8000 IU's of Vitamin D3 supplement and not the drug Asentar

file:///C:/Users/gus/Downloads/Chemotherapy%20and%20vitamin%20D%20-%20review%202010.pdf

[Dan59 in reply to gusgold]

ascopubs.org/doi/abs/10.120...

From what I read on your news article , they used Calcitriol which they mention is an active form of D3, In this peer reviewed phase 3 paper from Sloan Kettering they also used calcitrol

Asentar was nothing more than a brand name for Calcitriol . Calcitriol being the bioactivated form of vit D3. If you think about it, they did a lot of studies on this adding cacitriol (vit D) to chemo, and for some reason it did not pass the FDA, otherwise it would be SOC , just saying. I suspect that Patrick is right and that using cholecalciferol instead of calcitriol may have had a different outcome, I do not see studies of that however. Gus, Your links do not come up in past few post of yours.

[gusgold in reply to Dan59]

You have to consider no drug company is going to fund clinical trials using Vitamin D3 and over the counter supplement

[Hidden in reply to gusgold]

It would be easy enough to test D3 without funding. In the case of the study you mention, they could have created an arm that used D3 rather then calcitrol.

[gusgold]

file:///C:/Users/gus/Downloads/vitamin%20D%20use%20with%20chemotherapy%20-%20July%202010.PDF

[Hidden]

I like your blood pressure numbers. My bp is usually 135/70 on ramipril and hydrochlorothiazide. But it does vary for no particular reason (108/62??).

I do take D3 but not for BP. Do you think it helps the BP?? I go 5000IU+, but don't know why, except for Bruce Hollis's video.