New study below.
{Recap: the epithelial-to-mesenchymal transition [EMT] is implicated in metastasis & treatment resistance.}
It always seems strange to me when a micronutrient is given to men without regard to the status of the nutrient in the body.
However, the men were Dutch & (unlike the U.S. & Canada) bread in the Netherlands is very low in selenium.
In fact, an intervention of "300 µg selenium per day ... {for} 5 weeks" had a profound effect, suggesting that the selenium status had been generally poor.
"Prostate biopsies collected from the transition zone before and after intervention were analysed"
"... the intervention with selenium was associated with down-regulated expression of genes involved in cellular migration, invasion, remodeling ..."
"our explorative data showed that selenium affected expression of genes implicated in EMT in the transition zone of the prostate"
...
-Patrick
[1] ncbi.nlm.nih.gov/pubmed/280...
Oncotarget. 2017 Jan 6. doi: 10.18632/oncotarget.14551. [Epub ahead of print]
A short-term intervention with selenium affects expression of genes implicated in the epithelial-to-mesenchymal transition in the prostate.
Kok DE1, Kiemeney LA2,3, Verhaegh GW3, Schalken JA3, van Lin EN4, Sedelaar JP3, Witjes JA3, Hulsbergen-van de Kaa CA5, Van't Veer P1, Kampman E1,2, Afman LA1.
Author information
1Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands.
2Department for Health Evidence, Radboud University Medical Center, Nijmegen, The Netherlands.
3Department of Urology, Radboud University Medical Center, Nijmegen, The Netherlands.
4Strahlentherapie Bonn Rhein Sieg, Wesel, Germany.
5Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
Abstract
In parallel with the inconsistency in observational studies and chemoprevention trials, the mechanisms by which selenium affects prostate cancer risk have not been elucidated. We conducted a randomized, placebo-controlled trial to examine the effects of a short-term intervention with selenium on gene expression in non-malignant prostate tissue. Twenty-three men received 300 µg selenium per day in the form of selenized yeast (n=12) or a placebo (n=11) during 5 weeks. Prostate biopsies collected from the transition zone before and after intervention were analysed for 15 participants (n=8 selenium, n=7 placebo). Pathway analyses revealed that the intervention with selenium was associated with down-regulated expression of genes involved in cellular migration, invasion, remodeling and immune responses. Specifically, expression of well-established epithelial markers, such as E-cadherin and epithelial cell adhesion molecule EPCAM, was up-regulated, while the mesenchymal markers vimentin and fibronectin were down-regulated after intervention with selenium. This implies an inhibitory effect of selenium on the epithelial-to-mesenchymal transition (EMT). Moreover, selenium was associated with down-regulated expression of genes involved in wound healing and inflammation; processes which are both related to EMT. In conclusion, our explorative data showed that selenium affected expression of genes implicated in EMT in the transition zone of the prostate.
KEYWORDS:
EMT; gene expression; microarray; prostatic neoplasms; selenium
PMID: 28076331 DOI: 10.18632/oncotarget.14551
[PubMed - as supplied by publisher]
