Experiences with

Chemoprevention

This study demonstrates that combining Arc with GT and Q was highly effective in prostate cancer chemoprevention. These results warrant clinical trials to confirm the efficacy of this combination in humans.

Overall, the MTA1-targeted strategies involving dietary stilbenes may be valuable for effective chemoprevention in selected subpopulations of early stage prostate cancer patients and for combinatorial strategies with conventional chemotherapeutic drugs against advanced metastatic prostate cancer.“

A 2018 reviewTrusted Source of in vitro, in vivo, and human studies demonstrated the potential benefits of tea polyphenols in the chemoprevention of UVB-induced skin cancer.

However, as an effect of post diagnostic use of anti-hypertensive drugs, angiotensin Ⅱ receptor blockers(ARBs)was associated with improved overall survival and cause specific survival, which means the second chemoprevention potential for Pca.

SFN is a histone deacetylase (HDAC) inhibitor and has been recognized as an antioxidant and antitumor compound for chemoprevention. However, its antiviral effect is less well elucidated.

ALCAR is a widely diffused dietary supplements and our findings provide a rational for studying ALCAR as a possible molecule for chemoprevention approaches in subjects at high risk to develop prostate cancer.

Keywords: Anti-inflammatory agents; Aspirin; Cancer risk; Chemoprevention; Effect modification; Non-steroidal. Grant support ZIA CP010128/ImNIH/Intramural NIH HHS/United States

[/i]" [6] (2016) Bioactive natural products for and treatment of castration-resistant prostate cancer "[i]Nutraceuticals that target AR signaling (epigallocatechin gallate [EGCG], curcumin, and 5α-reductase inhibitors), AR synthesis (ericifolin, capsaicin and others) or [u]AR degradation

Our findings provide the rational for the employment of ALCAR, as a possible supplement for approaches of chemoprevention in subjects at high risk to develop cancer. Citation Format: Adriana Albini, Antonino Bruno, Denisa Baci, Matteo Gallazzi, Matilde Tramacere.

Taken together, our findings also raise a cautionary concern for the design of prospective intervention biomarker-based chemoprevention clinical trials.

Prostate Cancer Disparity, Chemoprevention, and Treatment by Specific Medicinal Plants Clement G. Yedjou 1,*OrcID, Ariane T. Mbemi 1, Felicite Noubissi 2OrcID, Solange S. Tchounwou 3, Nole Tsabang 4, Marinelle Payton 5, Lucio Miele 6 and Paul B.

This enthusiasm is reflected in the initiation of the Selenium and Vitamin E Chemoprevention Trial (SELECT)." So in 2002 (we are led to believe), a significant number of U.S. men were using selenium to prevent PCa.

Both forms of vitamin E (and others) should be thoroughly evaluated in the future to provide the most effective chemoprevention information to the patient."

potential" "The quenching of ROS generation with antioxidant N-acetyl-L-cysteine conferred significant protection against sulforaphane-induced ROS generation" [NAC] "Discordant results in preclinical and clinical trials have raised questions over the effectiveness of antioxidants in prostate cancer chemoprevention

Taken together, evidence shows that CA has multiple protective effects, which can be further explored and developed towards PCa chemoprevention. 3.1.3.

"The current study is the first to implicate inhibition of fatty acid synthesis in prostate cancer chemoprevention by PEITC."

In the nonsurgical realm, the long-term use of birth control pills — known as chemoprevention — is effective, has a low complication rate and is appropriate regardless of someone’s level of cancer risk, Cass said.

First a recap of the REDUCE trial: "The Reduction by Dutasteride of Prostate Cancer Events clinical trial is an international, multicenter, double-blind, placebo controlled chemoprevention study designed to determine if dutasteride 0.5 mg daily decreases the risk of biopsy detectable prostate cancer.

The ability of SFN to target aberrant acetylation patterns, in addition to effects on phase 2 enzymes, may make it an effective chemoprevention agent." [3e] (2011 - U.S.)

KEYWORDS: Anti-cancer herbal preparation; androgen receptor; caspase-8; chemoprevention; prostate cancer PMID: 27705939 DOI: 10.18632/oncotarget.12393