hindawi.com/journals/mi/201...
Any other members with prostate cancer also suffer from gout? Had first flare of gout at age 39 and diagnosed with prostate cancer at 44. Gout appears to be a risk factor for cancer, particularly prostate cancer. See link. Other research concurs.
The link you provided is very interesting, but not really surprising. There is a lot of evidence that inflammation is related to cancer and gout is an inflammatory condition.
Joel
I have had mild gouty episodes. Only one serious one that took me to a doctor. Excruciating pain in the heel of the left foot. Usually, I feel a mild pain in the big toe of that foot, so thought it might be something else.
The foot doctor diagnosed it & said that the pain would go away if I had a break from the foods I had been eating. Offered no medication.
I had been uncharacteristically binging on foods high in purines - several things, but notably anchovies. In fact, the foods were also high in glutamates - the stuff that adds umami (the "fifth taste") to food. I doubt that purines were the attraction.
Purines (& glutamates) are everywhere, but some foods have high concentrations. Purines metabolize to uric acid, & monosodium urate crystals lodge in the affected areas to cause the pain.
Growing up in England, my introduction to gout was from 18th century cartoons of wellfed country squires, afflicted foot on pillow, feasting on stilton & port - both, rich in purines.
thedoctorweighsin.com/woes-...
The pictures were always of men at an age when they might well have also had prostate issues. But when I searched GoogleBooks for urological textbooks from the 18th & 19th centuries some years ago, I found plenty on benign inflammatory conditions, but nothing on cancer until the latter half of the 19th century.
Prostate cancer was first described in the April 23rd, 1853, issue of the Lancet, pages 393-4. Considered a rare condition - unlike BPH, which had been known for many centuries - cases did not become commonplace until the 1890's.
Willian Coulson in "ON THE DISEASES OF THE BLADDER AND PROSTATE GLAND", 1852"
"Cancer in any shape, observes Rokitansky, rarely occurs in the prostate, which is curious, as contrasted with the frequency of its occurrence in the uterus. Medullary carcinoma is occassionally found to attack the prostate, and to give rise to considerable enlargement of the gland; it may sometimes perforate the fundus vesicae, and sprout into its cavity, causing a cancerous ulcer, with raised edges and varying size. My own experience agrees with these opinions. I have met with cases of medullary cancer, but not of true scirrhus."
Scirrhus: a carcinoma that is hard to the touch.
A marked increase in gout occurred in England starting in the 17th century. Much has been written about it, since it was largely confined to the wealthy & educated. Consequently, one finds plenty of examples of sufferers who lived well beyond 70, but no association with PCa at all, since that disease was virtually unknown.
Gout is an inflammatary condition, & it's possible that circulating markers of inflammation might act as a PCa accelerant - not a cause, though.
Uric acid & PCa? A paper from March [1] concluded that:
"lowering {serum uric acid} levels in prostate cancer is likely to be therapeutically beneficial"
Whereas a 2014 paper [2] reported that:
"Higher levels of {serum uric acid} were associated with a lower risk of mortality from any cancer "
Studies that support the gout link.
[3] "The age-adjusted standardized incidence ratios" were: all cancers (2.26), prostate cancer (3.31), bladder cancer (3.14), and renal cancer (2.18).
[4] "After adjustment for age and sex, gout was found to be associated with a hazard ratio (HR) of 1.15 ... for cancer. Gout was most closely associated with prostate cancer, with an age- and sex-adjusted HR of 1.71"
Both studies are Taiwanese.
Effect of gout meds.
Colchicine:
[5] "Laboratory data indicate that colchicine has an antimetastatic effect". Author presents an anecdotal case.
[6] "Colchicine must be stopped before imaging with [18F]-methylcholine PET/CT."
Allopurinol:
[7] "Anti-gout agent allopurinol exerts cytotoxicity to human hormone-refractory prostate cancer cells in combination with tumor necrosis factor-related apoptosis-inducing ligand"
-Patrick
[1] ncbi.nlm.nih.gov/pubmed/269...
[2] ncbi.nlm.nih.gov/pubmed/249...
[3] ncbi.nlm.nih.gov/pubmed/248...
[4] ncbi.nlm.nih.gov/pubmed/220...
[5] ncbi.nlm.nih.gov/pubmed/176...
[6] ncbi.nlm.nih.gov/pubmed/210...
[7] ncbi.nlm.nih.gov/pubmed/190...
Somewhat ironic. Had an email from RevGenetics with 50% off their resveratrol product, Nitro250. Today only; code "WelcomeBack".
Actually mentions Dr Myers: "Dr Myers and others have recommended our Nitro250 Micronized Resveratrol ..."
Small print:
"... it is not recommended long term for people with a genetic pre-disposition to Gout"
Full caution below.
-Patrick
In studies, resveratrol is suggested to be a weak inhibitor of the P4503A4 liver metabolism system, which is of unknown significance for humans. Taking large amounts of resveratrol may increase blood levels of drugs that are usually metabolized by CYP3A4. This simply means that calcium channel blockers, statins, some immunosuppressant drugs, and erectile dysfunction drugs, may have increased blood levels. Please be cautious when taking resveratrol with anti coagulants or anti platelet drugs. An increase in adenosine availability is involved in resveratrol cardioprotection in rats. It maybe possible that an increase in adenosine can increase uric acid temporarily. As a caution, it is not recommended long term for people with a genetic pre-disposition to Gout
My brother had his gout diagnosed by a foot doctor 5 years after his seeds treatment for PC. Foot doctors are good at spotting gout.
Soy consumption and prostate cancer
Prostatitis , prostate cancer,
Prostate Cancer Activist/Mentor
Thanks to Prostate Cancer, I ________
