ART Salvage Radiotherapy (sRT) After Radical Prostatectomy (RP): Long-Term Results Of Urinary Incontinence, Toxicity And Treatment Outcomes

[RMontana]

Purpose

For patients with local recurrent disease after radical prostatectomy (35–54%) salvage radiotherapy (SRT) is the treatment of choice.

Materials and methods

Patients with biochemically recurrent prostate cancer after radical prostatectomy, who were treated with SRT (3D-CRT) at our institution between 1998 and 2012, were included in this retrospective cohort analysis. Primary endpoint was urinary incontinence rate.

Results

244 patients were included. Median follow-up after SRT was 50 months (range: 4–187 months).

Before start of SRT 69.7% of patients were continent for urine.

After SRT de novo urinary incontinence complaints (grade ≥ 1 - Spontaneous flow; Pads indicated) occurred in the respective acute ( 90 days) in 6.1% and 17.6% of patients.

The respective 5-year bPFS, OS, DSS and DMFS rates were

47.6%, Biochemical Free Survival rate

91.8% Overall Survival Rate

98.8% Disease Specific Survival rate and

80.5% Distant Metastisis Free Survival rate.

ncbi.nlm.nih.gov/pmc/articl...