I have TAK/GCA and take 25 mg per week methotrexate and 20 mg Prednislone. I am constantly having symptoms of cystitis but there is no infection present from the lab tests. I have read that this can be caused by the methotrexate irritating the bladder. I had to come off methotrexate couple years ago because if same symptoms. It is so debilitating and really getting me down now. I think I am going to have to come off the drug. I am waiting to hear from my consultant. Does anyone have an experience if this and, if so, what did you do. Many thanks.