Underactive thyroid..... Anyone's levels reduce... - Thyroid UK

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Underactive thyroid..... Anyone's levels reduced even with treatment?

Tderrick92 profile image
6 Replies

Hi I was diagnosed with an underactive thyroid with thyroid antibodies last year.I started on 25mg which increased to 50mg as my levels remained around 10 and didn't increase with treatment.

The last couple of months I have been extremely tired, brittle nails and suffering extreme heartburn, body aches and very susceptible to the cold. I went back to the doctors to complain and my latest thyroid test is showing my levels have dropped to 7!

There not stabilising or even remaining as they was but dropping, is this normal?

Is there more too this?

I've been increased to 75mg and told to see the doctor in a fortnight if still no improvement of my symptoms.

Is there anything I can do to help myself feel better?

What could it mean that the levels are dropping and not stabilising?

Thank you to anyone who replies!!

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Tderrick92 profile image
Tderrick92
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6 Replies
TiggerMe profile image
TiggerMeAmbassador

Welcome aboard,

When you start treatment you are looking to lower your TSH to around 1 which will suggest you have a suitable dose and then you really need to get a private full thyroid panel to see where your actual thyroid hormone levels are

So it is great that your GP has increased your dose as 50mcg is a starter dose, you will need another blood test 8 weeks after increasing to 75mcg, ideally book a blood test for as early as possible and don't take your levothyroxine dose until after the test, fasted, water only

Has your GP checked your ferritin, folate, B12 and Vit D levels as they all play a part it utilizing levothyroxine, they are often low in Hypo's

Auto immune hypo's often benefit from a gluten and or dairy free diet

Is there more too this? Yes, so much more!

Tderrick92 profile image
Tderrick92 in reply toTiggerMe

Thank you for your reply

My latest results are

Serum TSH level 2.87 mIU/L [0.27 - 4.2]

Serum free T4 level 7.5 pmol/L [12.0 - 22.0];

My previous was

Serum TSH level 2.97 mIU/L [0.27 - 4.2]

Serum free T4 level 10.9 pmol/L [12.0 - 22.0];

So you can the T4 level has reduced during treatment when it's meant to be going up with the levorthyroxine I believe,?

Tderrick92 profile image
Tderrick92 in reply toTderrick92

Sorry I also forgot to mention I had a full blood count for vitamins etc this time round and everything else is either normal or satisfactory

SlowDragon profile image
SlowDragonAmbassador in reply toTderrick92

Levothyroxine doesn’t “top up” your own thyroid output…..it replaces it

So you are likely to need further increase after next test …..unless extremely petite

Guidelines of dose Levo by weight

approx how much do you weigh in kilo

Even if we frequently start on only 50mcg, most people need to increase levothyroxine dose slowly upwards in 25mcg steps (retesting 6-8 weeks after each increase) until eventually on, or somewhere near full replacement dose (typically 1.6mcg levothyroxine per kilo of your weight per day)

cks.nice.org.uk/topics/hypo...

bnf.nice.org.uk/drugs/levot...

nhs.uk/medicines/levothyrox...

Adults usually start with a dose between 50 micrograms and 100 micrograms taken once a day. This may be increased gradually over a few weeks to between 100 micrograms and 200 micrograms taken once a day.

Some people need a bit less than guidelines, some a bit more

TSH should always be below 2 on levothyroxine

gponline.com/endocrinology-...

Graph showing median TSH in healthy population is 1-1.5

web.archive.org/web/2004060...

Comprehensive list of references for needing LOW TSH on levothyroxine

healthunlocked.com/thyroidu....

onlinelibrary.wiley.com/doi...

If symptoms of hypothyroidism persist despite normalisation of TSH, the dose of levothyroxine can be titrated further to place the TSH in the lower part of the reference range or even slightly below (i.e., TSH: 0.1–2.0 mU/L), but avoiding TSH < 0.1 mU/L. Use of alternate day dosing of different levothyroxine strengths may be needed to achieve this (e.g., 100 mcg for 4 days; 125 mcg for 3 days weekly).

sciencedirect.com/science/a...

The optimal daily dose in overt hypothyroidism is 1·5–1·8 μg per kg of bodyweight, rounded to the nearest 25 μg.

Please add actual vitamin D, folate, ferritin and B12 results

TiggerMe profile image
TiggerMeAmbassador in reply toTderrick92

Do you always leave 24hours after last dose before testing?

Yes, you are looking for TSH to come down and fT4 and fT3 to rise

The essential bit of the puzzle is missing as you really need to know how well you are converting T4 (storage) into the active fT3 hormone

greygoose profile image
greygoose

Do you always take your levo on an empty stomach and wait at least an hour before eating or drinking anything other than water? Do you take other medication/supplements at least two hours away from levo - four hours for iron, calcium, magnesium, vit D and oestrogen?

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