Hi everyone.
Just wondered if anyone has done any research on Glycans?
Im just delving into this subject and found an interesting papers which seem to make a link between AITD and the malfunction of some of the glycans. The paper is heavy going but it seems that They are very much linked to Trab and TPOab levels in Hashis and Graves. I'll put the links below, but wondered if any of you have any thoughts on this. Is there such a thing as a Glycans Blood test??
hey there.
I have noticed you have waited for a while for a reply.
I’m tagging helvella and jimh111 who might know or who to ask.
Thankyou
I don't think I can understand that paper sufficiently to make any useful comments on it!
However, this whole area is relevant in two facets of thyroid disorder. First, although we all tend to talk of "TSH", that can be produced with varying glycosylation. Although that is known, it is mostly ignored.
And myxoedema is caused by higher-than-usual levels of glycans which retain water and cause swelling.
Yes its quite heavy but my takeaways from it were:-
The glycans are necessary for the receptor trafficking to the plasma membrane and binding of TSH to the receptor.
TSHR is the main autoantigen in Graves’ disease (GD), one of the thyroid autoimmune diseases.
N-oligosaccharides are the important part of THSR (Thyroid Stimulating hormone receptor) molecule, necessary for the proper functioning of receptors and probably involved in thyroid autoimmunity in GD.
The glycan part is essential to TSHR function
Therefore, it can be concluded that the presence of N-glycans is indirectly needed for
the attachment of TSH and may affect the binding of TRAbs in GD
I doubt its really relevant.
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