Regulatory Effects of 5-Day Oral and Intraperit... - Thyroid UK

Thyroid UK

140,948 members166,081 posts

Regulatory Effects of 5-Day Oral and Intraperitoneal Administration of a Thienopyrimidine Derivative on the Thyroid Status in Rats

helvella profile image
helvellaAdministrator
6 Replies

Why would you want to read this? Well, it suggests a way of treating some hypothyroid issues without affecting the thyroid itself. Very much related to the issues discussed in this very recent post:

How does taking thyroid hormone switch off our own hormone production?

healthunlocked.com/thyroidu...

The substance is, more or less, equivalent to TRH (TSH releasing hormone, also called thyroliberin). If the person isn't producing enough TRH, they won't produce enough TSH, hence will not produce enough thyroid hormone - and they will be hypothyroid.

But if the TRH is replaced/supplemented, the entire rest of the system can function as if there were no issue.

The problems being the substance used, how it can be delivered, how the dose can be managed, and - of course - whether there are other issues caused by adopting this approach.

Obviously this is not a suitable approach if the person doesn't have a working thyroid. So unlikely to help in cases of thyroid cancer, post-thyroidectomy and autoimmune thyroid disease which causes the destruction of the thyroid. But might be extremely valuable to some.

Bull Exp Biol Med. 2024 Sep 12.

doi: 10.1007/s10517-024-06223-8 Online ahead of print.

Regulatory Effects of 5-Day Oral and Intraperitoneal Administration of a Thienopyrimidine Derivative on the Thyroid Status in Rats

K V Derkach 1 , V N Sorokoumov 2 , I Yu Morina 2 , V S Kuznetsova 2 , I V Romanova 2 , A O Shpakov 2

PMID: 39266923 DOI: 10.1007/s10517-024-06223-8

Abstract

In experiments on rats, we studied the effect of 5-day intraperitoneal (15 mg/kg/day) and oral (40 mg/kg/day) administration of compound TPY3m, a stimulator of the production of thyroid hormones by the thyroid gland developed by us, on the blood levels of thyroxine, triiodothyronine, and thyroid-stimulating hormone and on morphology of the thyroid gland. With both routes of administration, TPY3m caused a sustained moderate elevation of thyroid hormones, mainly thyroxine, with little effect on the level of thyroid-stimulating hormone. TPY3m did not reduce the stimulating effect of thyroliberin on the levels of thyroid hormones and had no damaging effect on the thyroid gland. During long-term administration, compound TPY3m stimulates the production of thyroid hormones without weakening the activity of the thyroid axis. Thus, TPY3m is a prototype of drugs for correcting thyroid hormone deficiency.

Keywords: allosteric agonist; hypothyroidism; thyroid gland; thyroid-stimulating hormone receptor; thyroxine.

Written by
helvella profile image
helvella
Administrator
To view profiles and participate in discussions please or .
Read more about...
6 Replies
linda96 profile image
linda96

thank you Helvella, interesting paper. Did you note if they ever would use it in humans at all?

helvella profile image
helvellaAdministrator in reply tolinda96

I'm sure that is in their plans.

Russian research often doesn't make it to us - and prospects for more research and closer cooperation look bleak at present.

TSH110 profile image
TSH110 in reply tohelvella

Why do you think they are looking into it?

helvella profile image
helvellaAdministrator in reply toTSH110

Because moving from initial animal trials, through to human trials is the usual path. They seem quite excited.

Even if it is not those individuals, research of an actual research drug indicates someone has bothered to produce it, and someone has paid for it to be done. That usually implies an eventual target of its use in human and/or veterinary work in future - if it gets through trials. And then actual use will be dependent on commercial decisions.

TSH110 profile image
TSH110 in reply tohelvella

Well it is ground breaking stuff if all goes well with trials, so they ought to be chuffed.

Alas of no value to me, even if I lived long enough for it to be used in humans.

TSH110 profile image
TSH110

interesting, poor mice - as ever, but a bit more imaginative than the anti t3 and NDT brigade here who seem to think thyroid disorder is licked with their gold standard Levothyroxine and TSH, despite their patients telling them otherwise

Not what you're looking for?

You may also like...

Development of Low-Molecular-Weight Allosteric Agonist of Thyroid-Stimulating Hormone Receptor with Thyroidogenic Activity

A very interesting paper. A substance which has a similar impact on the TSH receptor as TSH. Which...
helvella profile image
Administrator

Thyroid-stimulating hormone (TSH) regulates hepatic bile acid homeostasis via SREBP-2/HNF-4α/CYP7A1 axis

Just a little something to think about while cooking or eating turkey. Or nut roast. Or whatever...
helvella profile image
Administrator

The Nutritional Supply of Iodine and Selenium Affects Thyroid Hormone Axis Related Endpoints in Mice

Good to see some more research on these issues. I suspect a lot of the standard picture of selenium...
helvella profile image
Administrator

Exploratory analysis of the associations between urinary phytoestrogens and thyroid hormones among adolescents and adults in the USA

First, this is a bit of an oddity - a paper from China about health in the USA. Second, a paper...
helvella profile image
Administrator

The effect of antiepileptic drugs on thyroid function in children

Interactions between everything to do with thyroid (hormones, tests, etc.) and medicines has often...
helvella profile image
Administrator