Interesting paper

[Murphysmum]

Apologies if this has been posted somewhere before.

This is an American paper looking at Canadian policy, but as a T3 only patient, and as I still have issues now and again (like this week!) I found the content very interesting.

I’m actually now wondering whether I trial 60mcg split into 3 rather than twice daily. I’ll think about that.

I really have to read this again to get my head around it, and for me the faster vs fed state stuff is actually more relevant than the bio equivalence stuff, but I hope it’s useful anyway.

Thyroid Patients Canada

Canadian LT3 brands: TEVA vs. Cytomel bioequivalence, fasted vs. fed

wp.me/pa3Fv5-ao5

[ Admin added title of linked item. ]

[FallingInReverse]

This is an incredible article, thank you for sharing.

Even the beginning, it sheds light on the ‘controversy’ around whether we can take T3 with food or if it needs an empty stomach.

I will def take time to read the rest. So much good stuff!

Scanning the footnotes also seems legit. It has Bianco listed. I think we all generally like Bianco?? I also want to look at how “new” any of the sources are.

Interested to see other forum opinions.

[jimh111]

Not had time to read it, just look at the pictures! Some years ago patients used to suggest taking liothyronine with food to slow down absorption, it appears their hunch was right.

[tattybogle in reply to jimh111]

Maybe Bianco should have a go at making "T3 brownies" .... they would be much easier to cut up into eights than tiddly 25mcg tiromel .

[Yostie in reply to tattybogle]

Shame we can't make our own "T3 brownies"! My T3 has (been) changed from TEVA to Strides Pharma UK - they just crumble....

[Murphysmum]

it certainly made me wonder if I should take my morning dose with food - if anything this is the time I’ll feel a “rush” when it kicks in. I’ve never really noticed it other times of day for a long time, but then I probably have some food in my stomach for the rest of the day.

As I said, I need to read it again too to properly get my head around it, but it is a very good article, and has arrived at a time when my levels are fluctuating and I’m considering changes, so it’s very interesting.

[Marz]

Repeating a paper is good in case someone missed my post of 3 days ago !! No apology needed 🌻

[Murphysmum in reply to Marz]

Lol, apologies to you then!

To be fair, I dip in and out of here, usually depending on my state of wellness, so I do miss stuff.

It’s a good paper though, very interesting. Well found! 😆

[Marz in reply to Murphysmum]

You can sign up to Thyroid Patients Canada Newsletter so you do not miss the wonderful work by Tania Smith. The much missed diogenes posted her work often and valued her contributions. You will find more of her articles by clicking onto diogenes and scrolling through his posts.... 😊

[Murphysmum in reply to Marz]

Agreed, I have looked at diogenes posts on occasion - I need to remember that resource is there

[Marz in reply to Murphysmum]

Signing up for Newsletters will keep you up to date....

[Murphysmum in reply to Marz]

I have for many years, thanks ☺️

[Bertwills]

I think it’s a really important article, I will certainly be taking my T3 with food though it does say that a higher dose might be needed so testing is, as ever, important.

It’ll actually make life much easier, taking a tablet when I eat is so much better than trying to remember to take it away from food. I’m still going to be careful about the timing of supplements though as they’re so concentrated.

Thanks for highlighting this article.

[Murphysmum in reply to Bertwills]

I’ve taken my dose this morning with my food.

As I’ve said to someone below, I’ve never really noticed as huge difference but I do get a “rush” it’ll be in the morning, not at night.

My levels are fluctuating a little recently despite my dose being constant, and so I think I’ll try sticking with the food+tablet for a few weeks and see what happens.

I’ll report back!

[lola1956]

I’m on t3 only and take my 75 mg 3x25 mg all in one dose every morning on empty stomach and I don’t drink tea for an hour after ! I’m very interested in this and will read fully later today, thank you for sharing 😊

[mstp]

I havent read the article yet but I have always taken my t3 immediately before breakfast. I just couldnt bear to wait an hour so I have been ignoring all the advice in that instance. It seems to work ok for me. In the early days I tried splitting the doses and that didnt work well but once I was on one dose a day (even with my breakfast) everything slotted into place. Thanks for letting us know about the article. I am looking forward to settling down with it this evening!

[Murphysmum in reply to mstp]

I have always intended to leave a gap in the morning of at least half an hour, but sometimes it isn’t possible.

I’ve never real noticed a discernible difference with or without food if I’m honest, but if I ever get a rush as I mentioned above, then it’ll be after my morning dose.

I took todays dose with my breakfast and I’ll monitor what happens for a few weeks

[nightingale-56]

When I was first put on Levo, 1997, the GP said to split my dose of 75mcg into 50 am after breakfast and 25 after dinner in evening. This did not seem to make any difference to absorption with my best ever symptoms. No vitamins or minerals were mentioned then either.

[thyr01d]

Thank you Murphysmum, I found this article very helpful and informative and am going to try taking my T3 with food.