Iron status, thyroid dysfunction and iron deficiency anemia: a two-sample Mendelian randomization study

[helvella]

Time and again, we see members with some level of iron deficiency and thyroid issues.

Here is a paper which identifies specific genetic causes. In this case, we desperate need the full paper to understand what they are really saying.

Ann Nutr Metab. 2024 Jun 10.

doi: 10.1159/000539610. Online ahead of print.

Iron status, thyroid dysfunction and iron deficiency anemia: a two-sample Mendelian randomization study

Xianjun Huang, Mingqiu Mao, Tianhong Guo, Yuqin Wu, Qi Xu, Junliang Dai, Yuanshuai Huang

PMID: 38857589 DOI: 10.1159/000539610

Abstract

Objective: Given the clinical association between thyroid dysfunction and iron deficiency anemia (IDA), as well as their shared association with iron status, this study aims to investigate the causal relationship between iron status and thyroid dysfunction, while also examining the risk of IDA in relation to thyroid dysfunction.

Methods: A two-sample Mendelian randomization (MR) study was conducted to identify the causal relationship of iron status on thyroid dysfunction, as well as thyroid dysfunction on IDA. Large-scale European population-based GWAS databases were utilized (Genetics of Iron Status consortium, ThyroidOmics consortium, FinnGen consortium, and UK biobank). Inverse variance weighted (IVW) was used as the main analysis. In addition, we used weighted median and MR-Egger to enhance the robustness. Sensitivity analysis was conducted to evaluate the robustness of MR results.

Results: The IVW estimates did not reveal any significant causal relationship between serum iron status markers and thyroid dysfunction. However, a significant causal relationship was observed between hypothyroidism and IDA (OR = 1.101, 95% CI = 1.048-1.157, p < 0.001). Repeated analyses also demonstrated a similar trend (OR = 1.023, 95% CI = 1.011-1.035, p < 0.001). Sensitivity analysis supported that the MR estimates were robust.

Conclusion: In our MR study, an upregulation of the hypothyroidism-associated gene was found to be significantly associated with an elevated risk of IDA in the European population. These findings may offer novel therapeutic insights for clinicians managing patients with hypothyroidism, IDA, or their comorbidities.

Currently the DOI link does not work and the paper has not yet been published.

pubmed.ncbi.nlm.nih.gov/388...

[Buddy195 Administrator]

Thanks for sharing helvella 👍