Interesting article on why women get higher lev... - Thyroid UK

Thyroid UK

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Interesting article on why women get higher levels of autoimmune disease

TSH110 profile image
8 Replies

Two versions:

Stanford Medicine-led study shows why women are at greater risk of autoimmune disease

Research throws light on the mystery of why women are much more prone to autoimmune disorders: A molecule made by one X chromosome in every female cell can generate antibodies to a woman’s own tissues.

med.stanford.edu/news/all-n...

VOA news

X Chromosome Linked to Autoimmune Diseases

voanews.com/amp/x-chromosom...

[ Added the titles from the linked pages to try to explain what is there and encourage members to follow them. ]

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TSH110
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humanbean profile image
humanbean

Note for readers - Xist is pronounced like "exist".

...

Your links were really interesting - thanks for posting. It was also shocking!

“Every cell in a woman’s body produces Xist,” Chang said. “But for several decades, we’ve used a male cell line as the standard of reference. That male cell line produced no Xist and no Xist/protein/DNA complexes, nor have other cells used since for the test. So, all of a female patient’s anti-Xist-complex antibodies — a huge source of women’s autoimmune susceptibility — go unseen.”

I thought that getting researchers to include women in their testing protocols was a major win. But it turns out that even our chromosomes are ignored in testing.

TSH110 profile image
TSH110 in reply to humanbean

Quite 😱 but perhaps in the future it will change for the better.

helvella profile image
helvellaAdministratorThyroid UK

Links neatly with my recent post which also goes on about the processes of shutting down one X chromosome.

Why Women Are Stripey - Epigenetics means women have different active x-chromosomes in different cells

healthunlocked.com/thyroidu...

TSH110 profile image
TSH110 in reply to helvella

Interesting, I had no idea the genes had to be shut down like that to avoid duplication from both X chromosomes in the woman until I read the article I posted. . I’ll have a pike at the link. For some reason I’m no longer notified when you have posted new stuff by HU - no idea why it stopped, so I now miss things ☹️

helvella profile image
helvellaAdministratorThyroid UK in reply to TSH110

I think there are ongoing issues with notifications. I keep thinking I should have had an alert. But then I sometimes get an alert and wonder why - because I've already seen it!

Not suggesting anyone should do this, but following me should ensure alerts.

If you are not getting them, do report the issue to HealthUnlocked.

Email support@healthunlocked.com or try the dropdown at top right.

This issue of reporting applies to ALL members.

humanbean profile image
humanbean in reply to helvella

What I can't understand with respect to alerts is why they keep going wrong. Why does the coding for alerts keep getting tinkered with? If something works it should be left alone!

TSH110 profile image
TSH110 in reply to humanbean

Fast typing? That’s all that matters these days 🙄

TSH110 profile image
TSH110

Fixed! For some reason the follow button for you was no longer checked 🤷🏽‍♀️

Excellent fault diagnosis there helvella 😊 Ta

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