omeprazole and levo: I need a bit of advice... - Thyroid UK

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omeprazole and levo

Kimkat profile image
20 Replies

I need a bit of advice please . I am going to have to change my times for taking Levo, I currently take it in the middle of the night, as I have to take Gaviscon directly before going to bed for gerd (I have a hiatus hernia) and first thing in the morning I have to take my Omeprazole. The reason I am having to change my Levo times is that it has started to disturb my sleep so badly that once I have taken it, I just can’t get back to sleep, so I am only getting around 3/4 hours a night now and I am constantly shattered. The question is, do I have to leave taking these 4hours either side of Levo? TIA

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Kimkat
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20 Replies
Forestgarden profile image
Forestgarden

You really need to take levo on an empty stomach. So I would say yes, you need the 4 hours before taking it. But the guidance says no food etc for 30 mins after levo, but I always leave an hour just to make sure I absorb as much as possible.

Kimkat profile image
Kimkat in reply toForestgarden

Thank you but it was the prior to and after taking Levo for omeprazole I am questioning. I need to take the omeprazole before I eat.

Forestgarden profile image
Forestgarden in reply toKimkat

Yes, so you could take your levo as soon as you wake up, then an hour later take your omeprazole before breakfast

Kimkat profile image
Kimkat in reply toForestgarden

I’m doing that at the moment but I leave it for 2 hours. Something in my head was telling me it was too soon 🤔

Kimkat profile image
Kimkat in reply toForestgarden

Yes Levo first, wait however long then omeprazole then wait 30 mins before food

Jaydee1507 profile image
Jaydee1507Administrator

Looking back at previous posts you seem to be poor converter and low FT3 can cause sleep issues amongst a host of other problems.

You had a great reply by SeasideSusie a while ago here: healthunlocked.com/thyroidu...

How is your ferritin, as that was low and also something that can cause problems?

I'd suggest you try and get referred or see a private Endo regarding getting some T3 added to your Levo. You can email info@thyroiduk.org for a list of T3 friendly Endo's.

If you could raise your FT3 then you might not need all the stomach acid suppressors.

People who are hypo often suffer from low stomach acid as opposed to too much. It can feel the same. You might try taking betain with pepcin to help raise your stomach acid or a teaspoon of apple cider vinegar (must contain the Mother) in a glass of water with meals.

If you can get rid of at least one dose of acid reducer/blocker then you can take your Levo at that point.

Kimkat profile image
Kimkat in reply toJaydee1507

I have to take gaviscon prior to bed otherwise I end up with a very painful and sore throat . I have reduced my omeprazole to one a day from two but if I stop that altogether I really suffer. I have tried the acv but that just gives me terrible stomach issues, real burning sensations. I just want to know the best times either side of Levo for taking gaviscon. I have tried looking on here but can’t find it.

Kimkat profile image
Kimkat in reply toJaydee1507

also to add I am just waiting for a new blood test to arrive from Medichecks.

Jaydee1507 profile image
Jaydee1507Administrator in reply toKimkat

It would be best to leave 1 hour after Levo before taking Gaviscon but if you could leave longer it would be better.

Kimkat profile image
Kimkat in reply toJaydee1507

Thank you, I take Gaviscon literally just before bed. I was more bothered about the omeprazole, not sure whether it’s 4 hours either side or maybe 4 before and 2 after, or vice versa. It’s so long since I read it I just can’t remember. Taking levo at 2-3 am was great until it started disturbing my sleep but now having to incorporate it into other meds routine and food is proving mind boggling.

Jaydee1507 profile image
Jaydee1507Administrator in reply toKimkat

If you do the same thing every day then get a blood test done 6-8 weeks following any changes you have made then that should work. You can adjust dose if necessary then.

Raising FT3 should be a priority and would likely help alot.

Kimkat profile image
Kimkat in reply toJaydee1507

Yes thank but I’m still not sure if the timings between Levo and omeprazole.

Jaydee1507 profile image
Jaydee1507Administrator in reply toKimkat

According to this article:

Because omeprazole reduces the amount of acid produced by your stomach, it results in decreased absorption of levothyroxine. Since the acid reduction effects of omeprazole last more than 24 hours, altering the time either medication is taken will not avoid the drug-drug interaction. If you take omeprazole to treat heartburn, make sure you inform your doctor. You may need to have your thyroid hormone levels checked more frequently and your dose of levothyroxine adjusted.

drugs.com/medical-answers/a...

Kimkat profile image
Kimkat in reply toJaydee1507

Yes I read that too but I think it was slowdragon that had advised on the timings, I’ve been frantically searching for that post but can’t find it. At the end of the day I need to take both meds but wanted to try and minimise any problems with taking the two too near to each other but thanks for your input.

SlowDragon profile image
SlowDragonAdministrator in reply toKimkat

Have you tried taking omeprazole at bedtime?

Kimkat profile image
Kimkat in reply toSlowDragon

I can’t as I take my gaviscon directly before I go to bed to stop the acid burning my throat

SlowDragon profile image
SlowDragonAdministrator in reply toKimkat

Omeprazole is to do the same thing

nhs.uk/medicines/omeprazole....

Gaviscon

nhs.uk/medicines/gaviscon/#....

They both treat high acid reflux

Discuss with GP?

Acid reflux when hypothyroid can be due to low stomach acid but many medics don’t understand this

How to test your stomach acid levels

healthygut.com/articles/3-t...

meraki-nutrition.co.uk/indi...

huffingtonpost.co.uk/laura-...

lispine.com/blog/10-telling...

Useful post and recipe book

healthunlocked.com/thyroidu...

Kimkat profile image
Kimkat in reply toSlowDragon

I have had conversations with the GP about this and he said to just stay with it as the ENT consultant has advised it. My voice was so bad at one point that I had to go to speech therapy.

Ellie-Louise profile image
Ellie-Louise

I was just wondering, do you get up in the night for the toilet? You could take your Levo then.

Kimkat profile image
Kimkat in reply toEllie-Louise

Fortunately no I very rarely need to

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