Anyone know anything about TRH ?

[Stace268]

Estrogen dominance and TRH is there a doctor that helps with this on NHS

[Buddy195 Administrator]

TRH Thyrotropin-releasing hormone is produced in the hypothalamus and stimulates the release of TSH, which then increases thyroid hormones. TRH influences energy balance, eating patterns, body temperature and bodily functions.

More information on the HPT axis (hypothalamic-pituitary-thyroid axis):

health.selfdecode.com/blog/...

Please remember that we cannot discuss named practitioners on the forum and any information on doctors will need to be provided via private message.

[Stace268 in reply to Buddy195]

What does this mean

TRH dysfunction?

[radd]

Stace268,

TRH stimulates TSH (as explained by Buddy195) and also prolactin. This can suppress other pituitary hormones but doesn't influence oestrogen directly.

Oestrogen can be seen as 'high' either through having elevated levels or not having enough opposing progesterone. High oestrogen risks raising binding globulins that can disable thyroid hormones from working as they should, and then the hypothalamus might respond by releasing more TRH to encourage further TSH and thyroid hormone.

Have you had oestrogen and progesterone tested and if so what day of your cycle was the blood drawn?

[Stace268 in reply to radd]

Would this defect in genetics mean require T4/T3

What does this mean in re genetics

[Stace268 in reply to radd]

I have progesterone implant, not had estrogen or progesterone tested

[radd in reply to Stace268]

Stace268,

These genetic results are common on this forum (I have exactly the same). Remember the body usually compensates in other ways so although these results show a double mutation, it doesn’t mean there is no response from the TRH-R, just that impairment risk is high and to an unknown degree. I wouldn’t worry about this and no, it doesn’t directly effect T4 to T3 conversion once you are medicating thyroid hormone replacement.

Regarding your previous post I had my T3 meds withdrawn twice and live in the same region as you. If you are tired of fighting for your meds and the worry of them being withdrawn again, you can purchase your own T3 from abroad without a prescription. If you ask, members will provide credible sources by DM only. Alternatively ask for a private endos detail who is sympathetic to our needs and again members will DM you their experiences. Your other posts indicate problems within your life and adequate T3 levels are essential in maintaining good mental focus and reducing anxiety.

Why are you worried about elevated oestrogen levels if you haven’t had them tested? Are you symptomatic?

[Stace268]

Yes symptomatic quite a lot, internal shakes, chest pain, slow heart beat just generally feeling very bad, is it worth showing GP results I am out of work due to symptoms and looking after son with autism and similar health problems so cannot afford to privately fund

COMT

[radd in reply to Stace268]

I doubt your GP would be interested or even understand these results.

Sometimes knowing of these mutations gives us more worry than not knowing. COMT is important in methylation and hence why your results suggest mutations might impair oestrogen clearance, but it’s not a given this will happen.

My COMT is slow too but I support it with adequate B vits and magnesium, clean diet and exercise. Basically if you live a healthy life style it will help support any genetic impairments relating to excess catechols. There are certain protocols such as supplementing DIM (didn't help me) and flaxseed (I love) to support liver detox, and flavonoids such as quercetin, rutin, and other (I can’t remember). I go with what my body best responds to such as anything with green tea in it.

DIO1 genes are good for T4 to T3 conversion and clearance of RT3 👍, but no results for DIO2. For further reading on COMT, etc, I would recommend ‘Dirty Genes’ by Ben Lynch who is king of methylation/MTHFR issues. I am moving house and my copy is packed away now so I can’t quote from it atm.

Sorry you feel so unwell ☹️

[Stace268 in reply to radd]

DIO2

Dio2

[Stace268 in reply to radd]

OK, yes I read some of that online about diet etc. I know T3 has stopped chest pain so whether that's because estrogen is not so dominant or because T3 is higher not even sure though suspect probably both.