More on Vit D

[diogenes]

This concludes that Vit D deficiency by itself does not CAUSE hypothyroidism but suggests more work is needed to find its propoer role in medication.

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ThyroidVol. 33, No. 11Original StudiesFree Access

The Effect of Vitamin D Supplementation on Hypothyroidism in the Randomized Controlled D-Health Trial

13 Nov 2023 doi.org/10.1089/thy.2023.0317

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Abstract

Background: Hypothyroidism is common, and in iodine-sufficient areas, it is primarily caused by autoimmune destruction of the thyroid gland. Observational studies have consistently shown an inverse association between serum 25-hydroxyvitamin D concentration and autoimmune diseases; however, there is a lack of evidence from randomized controlled trials to support a benefit of vitamin D supplementation, particularly for autoimmune thyroid diseases. We, therefore, aimed to assess the effect of vitamin D supplementation on the incidence of hypothyroidism.

Methods: We analyzed data from the D-Health Trial (n = 21,315), a randomized double-blind placebo-controlled trial of 60,000 international units per month of supplemental vitamin D3 among Australians aged 60 years and over. Hypothyroidism, a tertiary outcome of the D-Health Trial, was defined by treatment with levothyroxine, ascertained through linkage with the Australian Pharmaceutical Benefits Scheme. The outcome was time to first prescription of levothyroxine. We began follow-up at 12 months after randomization; people who had died or who had been dispensed levothyroxine during the first year were excluded. Flexible parametric survival models were used to assess the effect of vitamin D supplementation on hypothyroidism, overall and within strata defined by age, sex, body mass index, and predicted baseline vitamin D status.

Results: We included 17,851 participants in the main analysis (vitamin D = 8939; placebo = 8912). During a median follow-up of 4.1 years (interquartile range 4.1–4.1), 293 participants developed hypothyroidism (vitamin D = 138 [1.5%]; placebo = 155 [1.7%]). Vitamin D supplementation did not significantly reduce the incidence of hypothyroidism (overall hazard ratio [HR] 0.89; 95% confidence interval [CI] 0.71–1.12). There was some suggestion of an effect in females (overall HR 0.78; CI 0.58–1.06) but not in males (overall HR 1.06; CI 0.74–1.50; p interaction 0.20).

Conclusions: Vitamin D supplementation did not reduce the incidence of hypothyroidism overall; however, the possible beneficial effect observed in females warrants further investigation.

[DippyDame]

It's that word "Cause"!

[SlowDragon Administrator]

pity they didn’t test patients Vitamin D results

2000iu daily won’t maintain good vitamin D levels in everyone, especially those who are heading towards hypothyroidism

And test probably needs to start with younger age group and run for longer

[FallingInReverse]

Thanks for sharing! Great timing as I’m just now working on understanding and optimizing my Vit D!

[userotc]

So why deficiency MAY not cause it, elsewhere its reported that higher D levels (100-150 nmol/L) may prevent hypothyroidism and autoimmune thyroid disease grassrootshealth.net/blog/t...

And such levels have other benefits, of course.

I cant help but think that the late, great SeasideSusie would be all over this! 🙏

[greygoose in reply to userotc]

That article seems like another case of doctors/researchers putting the cart before the horse - something they're famous for!

Those with Low Thyroid Function were Much More Likely to be Vitamin D Deficient

Well, that's no surprise, is it. People with low thyroid function are likely to be deficient in a lot of nutrients, as we're always finding on this forum. I don't think this is any kind of proof that low vit D causes hypothyroidism. Or even that it suggests it. You could say the same thing about B12 or folate.

[Brightness14]

Interesting read. Back in 2006 I had my gallbladder removed and it was full of only calcium stones. When I asked why I was informed that it was lack of Vitamin d. I had it tested and true enough it was very low. Because I had no other illnesses I had never even heard of Vitamin D.

Fast forward to 2014 when I was found to have a lump on my thyroid and the TT followed in 2015. My thyroid had been working perfectly until it was removed which was unusual.

I never lacked iodine and had mine tested it was good. No Hashi or gut problems either.

None of my birth family had lack of Vit D but all have autoimmune problems. Who knows!

[Bearo]

GP found my vit D was “on the floor” when first tested in my early 60s, and treated/mistreated it with vit D 800 with calcium which probably didn’t help much (I don’t know, because it wasn’t retested). She failed to tell me, and I didn’t know at the time that I could request actual results, that my TSH was ‘ borderline’ hypothyroid.

So maybe some sort of link.