TPO levels/results

[Blackberrymoo]

hi, can TPO levels decrease on their own without any intervention? Does it matter how high or not the number is as long as it’s over the reference range?

[Jaydee1507 Administrator]

TPO or Tg levels also wax and wane over many years almost on a daily basis.

So long as its over the reference range then the test is positive and autoimmune thyroid disease is the diagnosis.

[greygoose]

Antibodies fluctuate all the time. And it doesn't mean a thing.

They tend to be highest during, or just after, an autoimmune attack on the thyroid, when they come along to clean up the debris in the blood. In between attacks, their numbers reduce.

[SlowDragon Administrator]

As per previous post

healthunlocked.com/thyroidu...

You need vitamin D, folate, B12 and ferritin levels tested

Plus coeliac blood test too

nice.org.uk/guidance/ng20/c...

1.1 Recognition of coeliac disease

1.1.1 Offer serological testing for coeliac disease to:

people with any of the following:

persistent unexplained abdominal or gastrointestinal symptoms

faltering growth

prolonged fatigue

unexpected weight loss

severe or persistent mouth ulcers

unexplained iron, vitamin B12 or folate deficiency

type 1 diabetes, at diagnosis

autoimmune thyroid disease, at diagnosis

irritable bowel syndrome (in adults)

first‑degree relatives of people with coeliac disease.