Autoantibodies in Atrial Fibrillation—State of the Art

[helvella]

Having read the article I linked to re psychotic disorders and antibodies:

Autoimmunity and psychotic disorders

healthunlocked.com/thyroidu...

Something made me wonder about other issues and I decided to check atrial fibrillation (including tachycardia). And found this summary/review paper - which is very recent:

Autoantibodies in Atrial Fibrillation—State of the Art

Int. J. Mol. Sci. 2023, 24(3), 1852; doi.org/10.3390/ijms24031852

mdpi.com/1422-0067/24/3/1852

There are several references to T4, thyroid, Graves disease, hyperthyroidism. But what jumped out at me was this:

Li et al. immunized rabbits with peptides from the extracellular loops of both β1-adrenergic receptors and M2-muscarinic receptors to produce both types of antibodies. Antibodies expression triggered sustained sinus, junctional and atrial tachycardias, but not AF. Sustained AF was induced by addition of excessive T4. Interestingly, AF induction was blocked by the neutralization of these antibodies despite continued hyperthyroidism.

Especially the underlined section.

We've seen a considerable number of members reporting they suffer AF. And that this happens the moment their thyroid hormone levels rise. While others seem to have nothing more than an elevated heart rate. Could the reason for this difference lie in presence/absence of these antibodies - at least in some people?

And I'd emphasise that this happens both in Graves disease and other disorder-based hyperthyroidism - as well as over-medication (and I implicitly assume the wrong balance of T4 and T3 with too much of either to constitute a form of over-medication).

[arTistapple]

OMG another paper highlighting the power and all cell consuming effects of thyroid hormones. When are medics going to start working with all this information? Instead, they put blocks on treatment when issues arise and in many cases what amounts to non-treatment? The medical world of endocrinology ought to be utterly ashamed of themselves,

[Poppy_the_cat]

Hello,

I've been in hospital for a week on drips (inflamed gallbladder/infection) ... I've been allowed the reward of removing the last of my cannulas myself!

Waiting for meds and discharge now.....

Ok, my Experience;

Silly GP's and how to handle them! Avoid them if you can!

When they go on to their system to order the 'thyroid test' we all know they just offer TSH.

However, there other options to choose in the same drop down box section... As I recall it is either 'Other' or 'Consultant'. Once you can click onto that option you should be on the home straight! It then reveals T3 and T4. You click on both options and get accepted.

However, you need a co-operative individual at the helm... My GPs are worse than useless. I would actually classify them as obstructive. The last one I saw in February said "all my pain was in my head".... "That I had had more tests than most and that I should count myself lucky and content myself with that!" I had never seen him and it was clear this astonishing revelation was the diagnosis he had formed before I'd even walked through the door.

The reason I'm here clearly indicates how shockingly absurd his diagnosis is.

People, particularly male doctors with this approach are only gaslighting people, so do not expect any help from them. The only reason I stay with the practice is because the extraordinarily intelligent and nutrition interested Nurse Practitioner is as brilliant as she is. She is my saving Angel and navigates the IT system accordingly, saying the T3 and T4 tests have been ordered by the consultant 😉😉 and the system accepts it.

Best of luck.

Kindest Regards

Any further questions just ask.

Poppy the 😺