Manufacturers of medication lexothroxine - Thyroid UK

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Manufacturers of medication lexothroxine

62chelat profile image
20 Replies

Hi everyoneThankyou for letting me join the group 😀

Has anyone had side effects from TEVA manufacturers when taking levothyroxine such as : sticky cough, throat tightening, feeling very hot and heavy upper arms. I'm wondering if I should ask for a different brand 🤔 I take 75 to 200 my daily thankyou, plus I have increased raised colestrol levels now ☺️

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62chelat
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SlowDragon profile image
SlowDragonAdministrator

welcome to the forum

Are you based in U.K.?

Yes many, many people react badly to Teva brand

Which other brands have you had previously

How much levothyroxine are you currently taking

Request new prescription and try different brand

Bloods should be retested 6-8 weeks after any brand change in levothyroxine

Many people find Levothyroxine brands are not interchangeable.

Most easily available (and often most easily tolerated) are Mercury Pharma or Accord

Mercury Pharma make 25mcg, 50mcg and 100mcg tablets 

Mercury Pharma also boxed as Eltroxin. Both often listed by company name on pharmacy database - Advanz 

Accord only make 50mcg and 100mcg tablets 

Accord is also boxed as Almus via Boots

Teva contains mannitol as a filler instead of lactose, which seems to be possible cause of problems. Mannitol seems to upset many people, it changes gut biome 

Teva is the only brand that makes 75mcg tablet. 

So if avoiding Teva for 75mcg dose ask for 25mcg to add to 50mcg or just extra 50mcg tablets to cut in half

But for some people (usually if lactose intolerant, Teva is by far the best option)

Aristo (currently 100mcg only) is lactose free and mannitol free. 

Wockhardt is very well tolerated, but only available in 25mcg tablets. Some people remain on Wockhardt, taking their daily dose as a number of tablets 

 

List of different brands available in U.K.

thyroiduk.org/if-you-are-hy...

Posts that mention Teva

healthunlocked.com/search/p...

Teva poll

healthunlocked.com/thyroidu...

Once you find a brand that suits you, best to make sure to only get that one at each prescription.

Watch out for brand change when dose is increased or at repeat prescription.

Government guidelines for GP in support of patients if you find it difficult/impossible to change brands 

gov.uk/drug-safety-update/l...

If a patient reports persistent symptoms when switching between different levothyroxine tablet formulations, consider consistently prescribing a specific product known to be well tolerated by the patient. 

academic.oup.com/jcem/artic...

Physicians should: 1) alert patients that preparations may be switched at the pharmacy; 2) encourage patients to ask to remain on the same preparation at every pharmacy refill; and 3) make sure patients understand the need to have their TSH retested and the potential for dosing readjusted every time their LT4 preparation is switched (18).

62chelat profile image
62chelat in reply toSlowDragon

Thankyou so so much for all this information. The doctors pharmacist is calling me Friday as I can't get to see my doctor 😫...I'm going to mention all this information. The problem started at Christmas when they gave me teva statins and I was on the teva throxeyn it seemed the two have caused a problem I can not tolerate the statins at the moment or my throxeyn I did read today about these fillers in the teva tablets and wondered if they are causing a blocked feeling throat and coughing it's not a virus or infection..😀 ...I'm in the UK normally on 75 mgs but the throyid latest test has just gone to 2.14 thankyou very much 😀 👍

SlowDragon profile image
SlowDragonAdministrator in reply to62chelat

TSH is too high

Are you taking levothyroxine on its own on empty stomach and nothing but water for at least an hour after

75mcg is only one step up from starter dose

How long have you been left on just 75mcg levothyroxine

You’re ready for next dose increase in levothyroxine to 100mcg

Was test done early morning and last dose levothyroxine 24 hours before test

What was Ft4 result?

on levothyroxine TSH should always be below 2

Approx how much do you weigh in kilo

Statins NOT recommended for hypothyroid patients

nhs.uk/conditions/statins/c...

If you have an underactive thyroid (hypothyroidism), treatment may be delayed until this problem is treated. This is because having an underactive thyroid can lead to an increased cholesterol level, and treating hypothyroidism may cause your cholesterol level to decrease, without the need for statins. Statins are also more likely to cause muscle damage in people with an underactive thyroid.

62chelat profile image
62chelat in reply toSlowDragon

Thankyou once again.I always take first thing in the morning with water and give myself an hour before anything to eat.

My recent blood test was done at 10 am so I had taken my dose as usual in the morning before hand.

4 months ago was my last test. Normally the Dr said every three months. I've been on

75 for 4 months now.

The statins before I stopped them for three months they put me on them because of heart history in our family ...the cholesterol has only gone up in recent months.

Results are 2.14 serum I guess I need to get it broken down.

Have had a fluid feeling in my head and bad headaches but when the dose increases it improves and tinnitus reduces.

Quite heavy at the moment but loosing weight on and off when the dose is right working hard to achieving loosing weight. Hardly eat much and the weight stays on. Bought a good book based on under active throyid meals. Thankyou 🌻 very much so helpful

SlowDragon profile image
SlowDragonAdministrator in reply to62chelat

My recent blood test was done at 10 am so I had taken my dose as usual in the morning before hand.

So TSH would have been even higher if tested around 9am

Falsely high Ft4 result (if GP tested) as you took levothyroxine before blood test

You need vitamin and antibodies tested too

Get retested, early morning and last dose levothyroxine 24 hours before test

List of private testing options and money off codes

thyroiduk.org/getting-a-dia...

Medichecks Thyroid plus antibodies and vitamins

medichecks.com/products/adv...

Blue Horizon Thyroid Premium Gold includes antibodies, cortisol and vitamins

bluehorizonbloodtests.co.uk...

If you can get GP to test vitamins then cheapest option for just TSH, FT4 and FT3

£29 (via NHS private service ) and 10% off down to £26.10 if go on thyroid uk for code

thyroiduk.org/getting-a-dia...

monitormyhealth.org.uk/

Monitor My Health also now offer thyroid and vitamin testing, plus cholesterol and HBA1C for £65 

(But Doesn’t include thyroid antibodies) 

monitormyhealth.org.uk/full...

10% off code here 

thyroiduk.org/getting-a-dia...

Only do private testing early Monday or Tuesday morning. 

Watch out for postal strikes, probably want to pay for guaranteed 24 hours delivery 

62chelat profile image
62chelat in reply toSlowDragon

Thankyou for all this advice the doctors don't tell you what to do. I will get retested. Have a good day 😊 👍

SlowDragon profile image
SlowDragonAdministrator in reply to62chelat

approximately how much do you weigh

Guidelines on dose levothyroxine by weight

pathlabs.rlbuht.nhs.uk/tft_...

Guiding Treatment with Thyroxine: 

In the majority of patients 50-100 μg thyroxine can be used as the starting dose. Alterations in dose are achieved by using 25-50 μg increments and adequacy of the new dose can be confirmed by repeat measurement of TSH after 2-3 months. 

The majority of patients will be clinically euthyroid with a ‘normal’ TSH and having thyroxine replacement in the range 75-150 μg/day (1.6ug/Kg on average).

The recommended approach is to titrate thyroxine therapy against the TSH concentration whilst assessing clinical well-being. The target is a serum TSH within the reference range. 

……The primary target of thyroxine replacement therapy is to make the patient feel well and to achieve a serum TSH that is within the reference range. The corresponding FT4 will be within or slightly above its reference range.

The minimum period to achieve stable concentrations after a change in dose of thyroxine is two months and thyroid function tests should not normally be requested before this period has elapsed.

Comprehensive list of references for needing LOW TSH on levothyroxine 

healthunlocked.com/thyroidu....

TSH should be under 2 as an absolute maximum when on levothyroxine 

gponline.com/endocrinology-...

NHS England Liothyronine guidelines July 2019

 

sps.nhs.uk/wp-content/uploa...

Page 9 

Test for Deficiency of any of the following: Vitamin B12, Folate,  Vitamin D, Iron

See page 13 

1. Where symptoms of hypothyroidism persist despite optimal dosage with levothyroxine. (TSH 0.4-1.5mU/L)

Graph showing median TSH in healthy population is 1-1.5

web.archive.org/web/2004060...

62chelat profile image
62chelat in reply toSlowDragon

Thankyou I feel as if I have so more much more knowledge from everyone's information very kind everyone . I'll report back once I've got this sorted and pills changed maybe ..I'm hopefull now that things might start to change for me thankyou 🙏 ☺️

Miffie profile image
Miffie in reply to62chelat

Like you I cannot tolerate Teva brand levothyroxine, I always understood it was the mannitol used as a filler that caused me to struggle.

However I am also unable to take Atorvastatin (Teva) or Simvastatin (Merk). in fact I can only tolerate Rosuvastatin. No mannitol in the statins I was assured it was something else. More than one GP/ pharmacist has assured me intolerance of different statin brands is very common. I believe this is the case with me, I also take Losartan and it’s often Teva brand I get with zero side effects. Over the years I have often had other Teva products with no issue.

You may struggle if you started the statin and levo at the same time to identify which causes the problems. I luckily discovered the statin problem sone year# after the levo. Good luck

helvella profile image
helvellaAdministrator in reply toMiffie

There is a specific genetic variant which particularly affects Simvastatin, and some other statins, and their effects on our bodies.

SLCO1B1 rs4149056

Effects of SLCO1B1 Genetic Variant on Metabolite Profile in Participants on Simvastatin Treatment.

europepmc.org/article/MED/3...

Miffie profile image
Miffie in reply tohelvella

Thank you helvella , as ever a font of amazing knowledge. 🙂

62chelat profile image
62chelat in reply tohelvella

Thankyou for this 😄

62chelat profile image
62chelat in reply tohelvella

Thankyou 😀

62chelat profile image
62chelat in reply toMiffie

Thankyou so helpful very grateful 🙏

Jaydee1507 profile image
Jaydee1507Administrator

Welcome to the group. It helps people to see where you're at if you complete your profile.

Teva can be an issue for many people. If you think it isn;t suiting you ask your GP to write on your prescription NOT TEVA brand.

Some of your symptoms sound like you might be under replaced. Do you have your most recent blood results? You are legally entitled to a copy of them. Ask at GP reception. Come back here and post the results with ranges - numbers in brackets.

62chelat profile image
62chelat in reply toJaydee1507

Thankyou so much for your help..I will do that. I'm uk 😀

helvella profile image
helvellaAdministrator

Follow this link and download my medicines document. It lists all UK thyroid medicines so you can see what is potentially available.

helvella.blogspot.com/p/hel...

62chelat profile image
62chelat in reply tohelvella

Thankyou for your help 🙏

mumellis profile image
mumellis

Yes it dried me out like a prune. Dry Skin, dry hair, dry cough, dry eyes and crippling constipation. Fine within a week of stopping it, coughwise and constipation, skin took longer. Back on Mercury Pharma so far but who knows when new pharmacist is found for local pharmacy. Probably back to the fight again!

62chelat profile image
62chelat in reply tomumellis

Thankyou these are also my symptoms so helpful to know this information 🙂

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