more information - chronic treatment with spironolactone causes a reduction in ischemic cerebral infarct size. Our hypothesis was that cerebral vascular structure is improved, via an increase in cerebral vessel lumen diameter, by chronic administration of spironolactone and that these changes would occur without a reduction in blood pressure. The MCA lumen and outer diameters were larger in the spironolactone-treated SHRSP compared to control SHRSP over the range of pressure.
There are two novel findings of this study:
1) Spironolactone treatment increases tone in the MCA of SHRSP and
2) Spironolactone treatment alters vascular structure of the MCA by increasing the lumen and outer diameters, without a change in blood pressure. When combined, these changes may explain the protective effects of spironolactone on the outcome of ischemic stroke, as observed previously by our laboratory
(Dorrance et al., 2000; Dorrance et al., 2001).
Spironolactone Improves Structure and Increases Tone in the Cerebral Vasculature of Male Spontaneously Hypertensive Stroke-Prone Rats
BTW - my blood pressure was usually 110-120 over 65-70 from my 20’s to 60’s until I had a heart attack at the age of 66. So bp measurement is not necessarily indicative of blood pressure in the brain.
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