New to liothyronine: I’ve recently been... - Thyroid UK

Thyroid UK

141,244 members166,489 posts

New to liothyronine

Roulette26 profile image
11 Replies

I’ve recently been prescribed lio, 10mcg twice a day plus 100mcg levo once a day. I take levo and lio when I wake, the second dose of lio at 5pm. I am finding that as the evening wears on I get very sleepy and have become prone to suddenly dropping off and waking maybe 1/2 hours later. Would it help if I moved the 2nd dose ? The only advice from the Endo was not to take it before bed, I’ve spent hours scouring the net and am becoming totally confused. I’d love to hear from others of their experiences.

Thanks in advance

Written by
Roulette26 profile image
Roulette26
To view profiles and participate in discussions please or .
Read more about...
11 Replies
SeasideSusie profile image
SeasideSusieRemembering

Roulette26

The only advice from the Endo was not to take it before bed

Did he say why?

There is absolutely no reason not to try taking it before bed, some members do and find it's better. Experiment to find the best time for you.

Roulette26 profile image
Roulette26 in reply toSeasideSusie

Thanks seaside Susie

DippyDame profile image
DippyDame

You started T3 about 28 days ago and it takes 6 to 8weeks for the hormone to settle into your system... initially, give it more time.

Have you optimised vit D, vit B12, folate and ferritin to support thyroid function?

Sadly there is no quick fix.

Timing your dose(s) is a very personal thing and often involves trial and error to find out what suits you best.

As for that endo's advice not to take T3 at bedtime...that is rubbish!

I take 100mcg T3 ( I have a form of thyroid hormone resistance/ RTH) at bedtime, my whole dose for the day, with no (sleep) problems.

CAVEAT - That dose however would be dangerous for non RTH patients!

10mcg is unlikely to cause problems...but experiment with timing

Test again after 6/8 weeks and review dose.

Roulette26 profile image
Roulette26 in reply toDippyDame

Thanks😀

SlowDragon profile image
SlowDragonAdministrator

Many people find it better to split T3 into 3 doses

Trial and error what suits each person

Lots of people find small 5mcg dose T3 at bedtime improves sleep…..but doesn’t suit everyone

Feeling sleepy after taking a T3 dose when initially starting on T3 ……it might improve after 2-3 months

If trying 3 doses

10mcg waking, 5mcg mid afternoon and 5mcg at bedtime

If bedtime dose keeps you awake….try waking noon and 6pm

At least Half an hour before food (ideally an hour)

What were thyroid and vitamin results BEFORE starting on T3

Bloods should be retested 6-8 weeks after each dose change or brand change in levothyroxine or T3

For full Thyroid evaluation you need TSH, FT4 and FT3 plus both TPO and TG thyroid antibodies tested.

Very important to test vitamin D, folate, ferritin and B12 at least once year minimum

Recommended on here that all thyroid blood tests early morning, ideally before 9am last dose levothyroxine 24 hours before test

On T3 or NDT - day before test split daily dose into 3 smaller doses, spread through the day at approx 8 hour intervals, taking last 1/3rd of daily dose 8-12 hours before test

This gives highest TSH, lowest FT4 and most consistent results. (Patient to patient tip)

Private tests are available as NHS currently rarely tests Ft3 or all relevant vitamins

List of private testing options and money off codes

thyroiduk.org/getting-a-dia...

Medichecks Thyroid plus antibodies and vitamins

medichecks.com/products/adv...

Blue Horizon Thyroid Premium Gold includes antibodies, cortisol and vitamins by DIY fingerprick test

bluehorizonbloodtests.co.uk...

Roulette26 profile image
Roulette26

TSH 3.53 (0.27-4.2)T3. 4.69 (3.1-6.8)

T4. 20 (12-22)

Folate. 5.94 (3.89-19.45)

B12. 96.8. (37.5-150)

VitD. 87. (50-200)

TPO <9. (0-34)

TPA. 14. (0-115)

Ferritin. 262. 13(-150)

My results are all over the place, when I was on 125 mcg levo TSH was nearer 2.26 , t4 20.8, t3. 4.07, but the Endo insisted I went on 100/125.

Ferritin nobody can give me an answer, 2 gps were checking it, another said it was normal! Searching seems to say menopausal women can be as high as 300.

I always do a Medicheck blood draw at the same time as nhs, so I can be somewhat prepared for the consultation.

Since starting T3 it’s like night and day. My mind is sharper, breathing almost back to normal and no more aches, pains and weakness in my hips and legs. Also energy levels have improved. Oh, and my hair has stopped falling out!

Roulette26 profile image
Roulette26

And you , thanks xx

shaws profile image
shawsAdministrator

This is a past link that you may find informative. One of Thyroiduk's Advisers - also a doctor, scientist, researcher and expert on T3 unfortunately died due to a bad fall which started a brain bleed and caused his demise and everyone who knew him or restored their health due to his advice were saddened.

healthunlocked.com/thyroidu...

Roulette26 profile image
Roulette26 in reply toshaws

Sorry for the late reply, I’ve been ploughing through the documents written by Dr Lowe, interesting.

radd profile image
radd

Roulette26,

Many have to experiment to find if one dose or several splits suits best and at what timings.

Your endo obviously isn't familiar with T3 dosing or would know some find a T3 bedtime dose helps them sleep better. You could try moving second dose later, ie 2 hours post eating, or split dose into three with the largest dose early morning to stay supporting adrenal glands, a smaller dose mid pm, and another at bedtime.

Roulette26 profile image
Roulette26 in reply toradd

Thanks, I’ve moved the second dose by a couple of hours, will keep trialing.

Not what you're looking for?

You may also like...

Liothyronine

Hi does anyone know where it states what brand of Lio a gp can prescribe now. Gps are adamant...
Denne profile image

New to T3

My new endo has started me on combi therapy (Yippee!), but proposes I take all of 20mcg of lio once...
paradime profile image

Ft3 level estimation

Hi. I took Levo c.28 hours before and Lio c.9 hours before a blood test at 9.30am. Unfortunately...
Sybilla14 profile image

T3 heart rate

I started T3 6 days ago. I’ve been prescribed 10 mcg split into two doses of 5mcg. So far I’ve...
Pearlteapot profile image

Due to start T3 but not sure of the best way to reduce my levo

I now have my T3 from the nhs Endo. My recent appointment by phone with her lasted about 5...
Oakwood4321 profile image

Moderation team

See all
Jaydee1507 profile image
Jaydee1507Administrator
PurpleNails profile image
PurpleNailsAdministrator
SlowDragon profile image
SlowDragonAdministrator

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.