Interesting article about thyroid testing

[CaroleM-A]

Interesting, although very scientific, article on thyroid testing, it’s limitations for diagnosis and treatment, and options for further testing to aid treatment for difficult to treat patients. Knowledge is out there, it just doesn’t seem to reach GPs, endocrinologists or the GMC!

://ncbi.nlm.nih.gov/pmc/articl...

[tattybogle]

Nice find Carole. I had read it a long while ago but forgotten about it.

Have just noticed it contains another useful reference to "optimal Levo replacement giving TSH <2 " to add to our list of references for this. SlowDragon SeasideSusie

And since its written by a bunch of boffins from Addenbrookes it is also hard to argue with.

"Given the complexity of pathways that govern TH action at tissue and cellular levels, it is not surprising that some patients receiving exogenous thyroid hormone replacement therapy report on-going symptoms despite optimal thyroid function tests

(e.g. normal T4 and T3 with TSH <2 mU/L in primary hypothyroidism).

In some of these it is conceivable that restoring euthyroidism in the HPT axis does not equate with resolution of hypothyroidism in other target tissues. For these individuals, and for patients with central hypothyroidism where TSH is not a reliable indicator, better tissue markers of TH action are required to help guide TH replacement strategies."

[thyreoidea]

Very informative, thank you.