Low triiodothyronine levels correlate with high B-type natriuretic peptide levels in patients with heart failure

[helvella]

An association between low T3 and cardiac disorders. They appear to very responsibly avoid unwarranted conclusions - which came first? - but at least the question is being asked.

• Open Access

• Published: 08 November 2021

Low triiodothyronine levels correlate with high B-type natriuretic peptide levels in patients with heart failure

• Hirotake Takahashi,

• Yusuke Kashiwagi,

• Tomohisa Nagoshi,

• Yoshiro Tanaka,

• Yuhei Oi,

• Haruka Kimura,

• Kousuke Minai &

• Michihiro Yoshimura

Scientific Reports volume 11, Article number: 21865(2021)

Abstract

Thyroid hormone metabolism can be closely associated with cardiovascular disorders. We examined the relationship between low triiodothyronine (T3) levels and heart failure status, including B-type natriuretic peptide (BNP) levels, in 625 patients with cardiovascular disorders who underwent cardiac catheterization. A multiple regression analysis revealed that the left ventricular ejection fraction (LVEF), hemoglobin (Hb) levels, sex (male), free T3 (FT3) levels, and estimated glomerular filtration rate (eGFR) were significantly negatively associated with the log BNP value, while age was significantly positively associated with the log BNP value (P<0.001 each). Furthermore, the log BNP and age were significantly negatively associated with the FT3 levels, while the Hb and body mass index (BMI) were significantly positively associated with the FT3 levels (P<0.001 each). Theoretically constructed structure equation modeling (SEM) revealed an inverse association between FT3 and BNP (β = −0.125, P= 0.002), and the same relationship remained in the patient group with normal-range BNP values (β = −0.198, P= 0.008). We demonstrated a significant relationship between high BNP and low serum FT3 levels, and this relationship remained significant in patients with normal BNP levels. These results indicate that low T3 is associated with high plasma BNP levels rather than worsening of hemodynamics.

Thankfully, Open Access here:

nature.com/articles/s41598-...

[Shusky]

So. By only treating with levothyroxine, only relying on TSH results and NOT worrying themselves with FT3, are endocrinologists helping to keep themselves and their medical colleagues in work 🤔 Certainly not helping their patients get healthier that is for sure 🤷‍♀️

[shaws Administrator in reply to Shusky]

I think the majority of NHS Endos were told not to prescribe NDTs and then T3 (now withdrwn altogether) by those we'd expect to have some brains or maybe they are low in T3 for their brains as the brain and heart have the most T3 receptor cells!