Calcitonin hormone and the thyroid.: A recent... - Thyroid UK

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Calcitonin hormone and the thyroid.

Read58 profile image
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A recent article released by the British Heart Foundation ( apparently a game changer) links lack of the hormone calcitonin with heart problems, including atrial fibrillation, strokes, etc. If Calcitonin is produced by a functioning thyroid , does this make us more susceptible . Tried reading up on mr google but still no clearer (to me anyway ).

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Read58 profile image
Read58

Thanks Scrumbler, thats excellent. Reassuring to know its not just produced in the thyroid. Thanks for taking the time to reply.

buddy99 profile image
buddy99

Have you tried pubmed? I found a lot of articles (did not read, though).

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Poniesrfun

This was of great interest to me as I have medullary thyroid cancer and the marker tested for recurrence is calcitonin. It was challenging to find good discussions. But what I did find is that the “calcitonin” produced by cardiac cells as discussed in the article is not the same as the bone-modulating calcitonin produced by C-cells in the thyroid. Thyroid calcitonin is “a 32 amino acid polypeptide hormone” while the cardiac “calcitonin” is caused by “Alternative splicing of the gene coding for calcitonin produces a distantly related peptide of 37 amino acids, called calcitonin gene-related peptide (CGRP), beta type. ”. Despite the similar name very different proteins and functions.

en.wikipedia.org/wiki/Amyli...

As the study abstract (the complete study is behind a paywall) does not make this distinction - in fact it conflates cardiac calcitonin gene-related peptide with thyroidal calcitonin, it’s no wonder the article author makes the same error - a disservice to thyroid patients.

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