Tania Smith's visitation on equivalence of DTE ... - Thyroid UK

Thyroid UK

141,244 members166,489 posts

Tania Smith's visitation on equivalence of DTE (NDT) and T4 in dosage

diogenes profile image
diogenesRemembering
10 Replies

It's often discussed on this forum what is the equivalence in dose effect of NDT and T4. Tania Smith's latest blog discusses this and sets out a table of conversion which the forum will find useful.

Written by
diogenes profile image
diogenes
Remembering
To view profiles and participate in discussions please or .
Read more about...
10 Replies
stiltzski profile image
stiltzski

Could you attach a link please? I can’t find it by googling for some reason...

helvella profile image
helvellaAdministrator in reply tostiltzski

Certainly:

thyroidpatients.ca/2020/05/...

I suspect it is simply too new and the search engines haven't yet indexed it.

TSH110 profile image
TSH110 in reply tohelvella

It is up there came in to me at 10:38 this morning to my inbox & link all fine

stiltzski profile image
stiltzski in reply tohelvella

Thanks very much.

TSH110 profile image
TSH110 in reply tostiltzski

Always put in - Dr Tania Smith thyroid - and you should get the home blog page linking to all her articles in date order from most recent, you can get email alerts set up, though I know they are not for everyone

humanbean profile image
humanbean

For example, the ATA decried Hoang’s failure to measure the “excursion” of T3 concentration potentially above reference 3 hours after a large DTE dose. Yet the ATA authors admitted that “The clinical consequences of such serum T3 excursions are unknown.”

What does "excursion" mean in this context? The thing being measured goes out of range? or is it specifically over the range?

diogenes profile image
diogenesRemembering in reply tohumanbean

It means in real language that taking T3 gives a short-lived spike in blood FT3 over the top of the reference range, shading down into normality soon after. It probably doesn't matter, being relatively short in duration. And the spike's metabolic effects will be slow to show themselves if indeed they do, because the effects won't have time to kick in before the FT3 has returned to normal. This is called a damped response.

humanbean profile image
humanbean in reply todiogenes

Thank you.

jimh111 profile image
jimh111 in reply todiogenes

When on high doses of L-T3 (up to 105 mcg daily, half am half bedtime) I monitored my pulse overnight. Although my pulse was higher than normal (~80 v ~72) I had no variation of pulse rate overnight. i.e. the fT3/tT3 spike that occurs approx 3 hours after L-T3 ingestion had no effect on my heart rate.

UrsaP profile image
UrsaP

Thank you for pointing this out

Not what you're looking for?

You may also like...

Pharmacokinetics of NDT (DTE)

I discovered some useful information on NDT pharmacokinetics (rate of uptake, time to achieve peak...
diogenes profile image
Remembering

Tania Smith's take on our recent model paper

Since I'm certain that some of this conversation with Tania Smith will be converted to an article...
diogenes profile image
Remembering

Rerun - Medscape and DTE (NDT)

Two years ago I posted an article from Medscape regarding the action of NDT (DTE) and its...
diogenes profile image
Remembering

Is this the last word on t3/t4 equivalence?

I have read various things about how much t3 equals how much t4 and have hedged my bets w the 3x-5x...

Parts 2 + 3 of Dr. Tania S. Smith's post on ratios of T4/T3

A further look at the point in question. PR Part 2...
PR4NOW profile image

Moderation team

See all
Jaydee1507 profile image
Jaydee1507Administrator
PurpleNails profile image
PurpleNailsAdministrator
SlowDragon profile image
SlowDragonAdministrator

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.