This downloadable paper discusses the history of the use of NDT and T4 in thyroid disease therapy. It never mentions FT3 and the thrust of the article implicitly is based on the current simple T4/TSH paradigm. Neverthelss it's a good history of the T4 story.
Thyroxine and treatment of hypothyroidism: seven decades of experience
July 2019 Endocrine 66(Suppl 2)
DOI: 10.1007/s12020-019-02006-8
The article doesn’t mention that the reason the FDA said L-thyroxine was a new drug in 1997 was because by then the FDA were fed up with the poor quality of Thyroxine tablets being produced. Tablets were unstable and lacked efficacy.
4 manufacturers managed to clean up their act by 2001, with Forest Pharmaceutical unable to comply with the new regulations. They were eventually bought out.
Thank you so much diogenes, I love 'History of'... Broda Barnes in "Hypothyroidism - The Unsuspected Illness" - provides insight into much, including keto bodies in urine (a huge topic now in light of Intermittent Fasting!). Mark Starr also gives some history in his book "Hypothyroidism Type 2". Indeed that book has as its epigraph "Those who can't remember the past are condemned to repeat it". - George Santayana (1863 - 1952).
Our Psychology Prof (physicist, who - due to the phenomena of fluctuations in pilot performance - became so fascinated by individual human differences, he switched discipline), gave us 'The History of Psychology' from Ancient Greek inquiry... right through to and including aspects of quantum physics as it relates to measurement. Coincidentally, our first year (began Joint Hons - transferred to Single) included Formal Logic and Theory of Knowledge which presented us with 'The History of Knowledge'. What a combination, eh? Also, inter alia, two years of every statistical test in existence (incl. Critical Path Analysis). Final year Bachelors included - Game Theories, probability, likelihood, inference and heuristics, Oh what happy days!
Despite the above being enticingly fascinating and notwithstanding further studies, I'm not quite sure how I'd have gotten through so much ignorant/arrogant sneering from some of the medical profession without that great grounding. As I occasionally quote, "I don't have to be a doctor to be able to tell 'sh*t from clay'.
Kristien Boelaert, talking about the recent issued NICE guidance mentioned that NDT would not be recommended as not licensed. I asked if it wasn’t licensed as it is a) a natural product and does not need licensing, and b) Predates the licensing act of the 30’s. It is a grandfathered product. Her response - she did not know about licenses.
Yet clearly happy to use this excuse for non recommended use in the Guidance.
Plus the 'unknown long term adverse effects’ - How can they not know this? When NDT is still in use and has been for all this time?
Conversion of t4 to NDT
