1) How does the pituitary gland send a message to the thyroid to alter t4 etc if you don’t have a thyroid
2) I’m staying on 100mcg as I said before but now when I take (in evening now not morning) it makes me feel nauseous why do you think that is, should I split the dose. Gp said I feel like that because I’m over medicated but on here I’m told I’m not.
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Goldengirl01
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If you have no thyroid at all, the dialogue between pituitary and body is entirely through controlling the body cells enzyme activity that converts T4 to T3. It does so through a TSH control mechanism directly concerned with how much and how active are the body's conversion of T4 to the active T3.
Well simply the pituitary can't influence the thyroid if it isn't there. The T4 you take is the only source and the body converts this to T3. The pituitary isn't directly involved at all but is a bystander.
So long as FT3 is well in range, what happens to TSH is much less important. Neither TSH nor FT4 are good diagnostics for T4 therapy. Or for combined therapy for that matter.
Since you do not have a working thyroid you have " lost " the known natural thyroid production of :- T1, T2, T3, T4, and calcitonin.
It is thought that a fully functioning working thyroid would be supporting you on a daily basis with approximately :- 100 T4 + 10 T3.
Your T4 needs to be high, or even over range, to be able to convert to a level of T3 you might find acceptable and that gives you back your " wellness ".
Your conversion maybe compromised if your ferritin, folate B12 and vitamin D are not optimal in the ranges.
Ultimately, even having all the above in place, you have " lost " that amount of T3 your thyroid produced, and it just seems logical to me, that people who have had a medical intervention and their thyroid surgically removed or ablated in situ with RAI should have both T3 and T4 on the prescription for if, and possible when, needed.
Our bodies run on T3, not a TSH or a T4 reading.
I read most people need about 40-50 T3 daily, to continue to have some QOL.
So, if on monotherapy with Levothyroxine and without a thyroid you have been automatically down regulated by about 20% of your potential well being, as you will have " lost that little bit of T3 " that your thyroid once produced.
I hope that makes some sense, and understand that the question follows on from your previous post from yesterday.
I appreciate there is a lot to take in and understand how hard this all can be when struggling with the brain fog of undermedication for hypothyroidism.
Why the nausea when taking Levo, I didn’t feel like this before, do you think the dose I’m on(100mcg) is adequate or does it mean I need an increase, or.........Does it mean I’m a pain in the A—- keep moaning, head fuzzy as well, OH B......s
I don't know - maybe the fillers - is it worth splitting and taking same dose but at either end of the day - what brand are you taking as I think many people on here have expressed dislike with certain brands, maybe someone will " chip in " or alternatively put your brand into the search engine and see if anything comes back - apart from your own post, if anything like me this morning !!
Im On mercury pharma, when they suggested alternate days of 75 that was the dreaded Treva but I didn’t take that for more than a couple of days then went back to mp. Just wondered if some food an hr after may help plus the fact I keep going hot (flushes like) but past menopause
Vitamins not too bad the D is the one I need to get up more but I’m using the spray for that and doubling the dose. I have omeprazole for stomach but haven’t taken it for a while as I didn’t want to much anything up but now you saying that I do on and off get burning sensation in stomach. I put my last bloods up but didn’t do tsh so I’m just going to pick it up now then I’ll post again
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